Obstructive Sleep Apnea
Conditions
Brief summary
Primary aim of the TURKAPNE (The Turkish Sleep Apnea Database) study is to generate a cross-sectional nationwide database to define clinical and polysomnographic characteristics of the sleep apnea patients in Turkey. Associations of phenotypes of sleep apnea patients with metabolic and cardiovascular diseases as well as risk for traffic accidents will be explored as secondary aims. Impact of treatment of sleep apnea on metabolic and cardiovascular complications as well as compliance with positive airway pressure treatment will be further explored longitudinally.
Detailed description
All subjects undergoing sleep study for suspicion of obstructive sleep apnea will be registered in a web-based national database regarding: * Anthropometric data, educational status, driving licence, * Smoking and alcohol use * Comorbidities, and drug use * Questionnaires, excessive daytime sleepiness * Polygraphic and polysomnographic findings * Blood pressure measurements * If taken, blood glucose, lipids and other biochemical markers * If measured, lung function test results * If measured, echocardiography findings * Follow-up data regarding treatment modality and compliance
Interventions
Treatment of OSA with PAP
DEVICEIntraoral device (IOD)
Treatment of OSA with IOD
PROCEDUREUvuloplasty
Uvuloplasty
OTHERConservative treatment
No active intervention
Sponsors
Ege University School of Medicine, Izmir, Turkey
Dokuz Eylul University
Diskapi Yildirim Beyazit Education and Research Hospital
Uludag University
Dicle University School of Medicine, Diyarbakir, Turkey
Namik Kemal University School of Medicine, Tekirdag
Suleyman Demirel University School of Medicine, Isparta, Turkey
Istanbul University - Cerrahpasa
Pamukkale University School of Medicine, Denizli, Turkey
Trakya University School of Medicine, Edirne, Turkey
Afyon Kocatepe University School of Medicine, Afyon, Turkey
Hitit University School of Medicine, Corum, Turkey
Istanbul Sureyyapasa Chest Diseases and Chest Surgery Training and Research Hospital
Kocaeli Education and Research Hospital, Kocaeli, Turkey
Baskent University Ankara Hospital
Marmara University
Koç University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Consecutive adult patients undergoing sleep study for suspicion of obstructive sleep apnea * Ability to read and speak * Signed informed consent.
Exclusion criteria
* subjects who use positive airway pressure * subjects with limited life expectancy due to advanced renal disease or uncontrolled malignancies * subjects with alcohol dependency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic and cardiovascular diseases in obstructive sleep apnea phenotypes | Up to three years | The association of sleep apnea severity indices such as Apnea-Hypopnea Index and Oxygen Desaturation Index during Rapid Eye Movement (REM) sleep and non-REM sleep with self-reported diabetes mellitus and cardiovascular diseases will be explored. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sex differences in obstructive sleep apnea phenotypes | Up to three years | Possible sex differences in REM-dependent sleep apnea, positional sleep apnea and its association with metabolic and cardiovascular diseases will be explored |
| Adherence to positive airway pressure treatment in obstructive sleep apnea | Through study completion, an average of 7 years | Predictors of adherence to positive airway pressure treatment (defined as device usage at least 4 hours of night during at least 70% of study period) in obstructive sleep apnea |
| Incidence of cardiovascular diseases and mortality | Through study completion, an average of 7 years | Number of patients who have died or developed cardiovascular diseases |
Countries
Turkey (Türkiye)
Contacts
Primary ContactYüksel Peker, Prof
Backup ContactBaran Balcan, Assoc. Prof
Outcome results
None listed