Fatty Liver
Conditions
Brief summary
Ultrasound (US) B mode image is an alternative method to measure tissue structure and has proven to be an accurate technique to measure subcutaneous fat thickness. However, pressing the transducer onto the skin with too much force will significantly reduce the subcutaneous adipose tissue thickness. In this study, a force controlled system combined with US transducer was used for 3D subcutaneous fat imaging and reconstruction.
Detailed description
The diagnosis of fatty liver (steatosis) is made when fat in the liver exceeds 5-10% by weight. Fatty liver (FL) is commonly associated with alcohol or metabolic syndrome (diabetes, hypertension, obesity, and dyslipidemia), but can also be due to any one of many causes. Most people were detected from serum lipid abnormalities in the physical examination, and confirmed as the fatty liver disease by ultrasound imaging. In some previous studies, ultrasound was reported to provide an accurate and reliable measurement tool for the thickness measurements of subcutaneous adipose tissue. This method can overcome some limitations of the skinfold thickness measurements. Ultrasound (US) B mode image is an alternative method to measure tissue structure and has proven to be an accurate technique to measure subcutaneous fat thickness. However, pressing the transducer onto the skin with too much force will significantly reduce the subcutaneous adipose tissue thickness. In this study, a force controlled system combined with US transducer was used for 3D subcutaneous fat imaging and reconstruction. Finally, the correlations between body fat percentage and subcutaneous fat in steatosis patients have been investigated. The body fat percentage was determined by dual energy X-ray absorptiometry (DEXA, GE Lunar iDXA canner) and bioelectrical impedance analysis (BIA, Omron，HBF-370), and then, the correlation between body fat percentage and subcutaneous adipose tissue in normal and steatosis patients have been evaluated.
Interventions
DEVICEUltrasound (US) B mode image
Ultrasound (US) B mode image is an alternative method to measure tissue structure and has proven to be an accurate technique to measure subcutaneous fat thickness.
Sponsors
Taipei Medical University
Taipei Medical University WanFang Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged between 20-65 adults who are confirmed have fatty liver by echo
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subcutaneous Fat in Steatosis Patients | up to 6 months |
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Fatty Liver Subjects Ultrasound (US) B mode image is an alternative method to measure tissue structure and has proven to be an accurate technique to measure subcutaneous fat thickness.
Ultrasound (US) B mode image: Ultrasound (US) B mode image is an alternative method to measure tissue structure
and has proven to be an accurate technique to measure subcutaneous fat thickness. | 30 |
| Total | 30 |
Baseline characteristics
| Characteristic | Fatty Liver Subjects |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 30 Participants |
| Sex: Female, Male Female | 21 Participants |
| Sex: Female, Male Male | 9 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 30 / 30 |
| serious Total, serious adverse events | 30 / 30 |
Outcome results
Primary
Subcutaneous Fat in Steatosis Patients
Time frame: up to 6 months
Population: fatty liver patients
| Arm | Measure | Group | Value (MEAN) |
|---|---|---|---|
| Fatty Liver Subjects | Subcutaneous Fat in Steatosis Patients | female__abdomen | 9.54 cm^3 |
| Fatty Liver Subjects | Subcutaneous Fat in Steatosis Patients | male__abdomen | 10.48 cm^3 |
| Fatty Liver Subjects | Subcutaneous Fat in Steatosis Patients | female__front thigh | 5.24 cm^3 |
| Fatty Liver Subjects | Subcutaneous Fat in Steatosis Patients | male__front thigh | 4.09 cm^3 |