Intraoperative Sedatives and Postoperative Pain

The Influence of Intraoperative Sedative on Postoperative Pain in Total Knee Arthroplasty Under Spinal Anesthesia: Comparison Between Dexmedetomidine and Propofol

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02784626

Enrollment

Registered

2016-05-27

Start date

2016-05-31

Completion date

2016-09-30

Last updated

2016-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arthritis, Degenerative

Keywords

Dexmedetomidine, Propofol, Pain, Postoperative

Brief summary

In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce postoperative pain in in patients undergoing the total knee arthroplasty.

Interventions

DRUGDexmedetomidine

Intraoperative sedation using dexmedetomidine

DRUGPropofol

Intraoperative sedation using propofol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing total knee arthroplasty * Age: 20 - 80 yrs

Exclusion criteria

* ASA classification ≥ 3 * Patient who do not want sedation during the surgery * Patient who wants general anesthesia * Cardiovascular disease * Liver dysfunction * Renal dysfunction

Design outcomes

Primary

Measure	Time frame	Description
Visual analogue scale	Postoperative 24 hours	Postoperative pain score at postoperative 24 hours

Secondary

Measure	Time frame	Description
Rescue analgesics	Postoperative 24 hours	Amount of rescue analgesics administered during 24 hours postoperatively
Visual analogue scale	Postoperative 48 hours	Postoperative pain score at postoperative 48 hours

Other

Measure	Time frame	Description
Nausea and vomiting	Postoperative 24 hours	Incidence of nausea and vomiting during 24 hours postoperatively
Antiemetics	Postoperative 24 hours	Amount of antiemetics administered during 24 hours postoperatively
Patient's satisfaction	Postoperative 48 hours	Patient's satisfaction with the pain management using a visual analogue scale (0 = very unsatisfied, 10 = completely satisfied)

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026