Parkinson Disease
Conditions
Brief summary
The investigators will investigate the effects of an 8-week resistant starch (RS) supplementation (5 g twice a day) in patients with Parkinson Disease and matched controls on: 1. symptoms of constipation (assessed by clinical scores); 2. fecal short chain fatty acid concentrations (measured by chromatography); 3. gut microbiota composition.
Interventions
DIETARY_SUPPLEMENTResistant starch
OTHERRecommendation with regard to nutrition
Subjects in this arm will receive General recommendations with regard to nutrition based on the guidlines of the German Society for nutrition
Sponsors
Universität des Saarlandes
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Main Inclusion Criteria: * Written informed to participate * For patients: diagnosis of Parkinson Disease Main
Exclusion criteria
* Use of antibiotics, steroids or probiotic supplements * Chronic or acute disorders of the gastrointestinal tract * History of gastrointestinal surgery (other than appendectomy) * For healthy controls: Family history of neurodegenerative disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bowel habits | 8 weeks | Number of patients with improved bowel habits |
| Fecal short chain fatty acid (SCFA) concentrations | 8 weeks | Number of patients with either a) increased, b.) unaltered or c) decreased concentration of short chain fatty acids in fecal samples at 8 weeks (compared to baseline) |
| Analysis of fecal microbiota composition | 8 weeks | Analysis to detect changes between baseline and 8 weeks of resistant starch supplementation |
Countries
Germany
Outcome results
None listed