Loss of Consciousness
Conditions
Keywords
Propofol, Dexmedetomidine, Dose, Bispectral index monitor
Brief summary
The purpose of this study is to evaluate the effects of different dexmedetomidine on the propofol requirement for loss of consciousness undergoing bispectral index.
Detailed description
It has been shown that dexmedetomidine was an efficacious and safe adjuvant in general anaesthesia. Administration of dexmedetomidine during the preoperative period has been demonstrated to reduce the requirement of opioid analgesics and other sedative and hypnotic drugs.Therefore, the study is designed to measure the effect of intravenous dexmedetomidine premedication on the propofol dose requirement and bispectral index at loss of consciousness.
Interventions
OTHERnormal saline
receive equal volume of normal saline
DRUGdexmedetomidine 0.5 µg/kg
receive dexmedetomidine 0.5 µg/kg
DRUGdexmedetomidine 1.0 µg/kg
receive dexmedetomidine 1.0 µg/kg
Sponsors
General Hospital of Ningxia Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status I-II * Aged 18-65 years * Body Mass Index 18.0～24.5 kg/m2 * Without hearing impairment
Exclusion criteria
* Bradycardia * Atrioventricular block * Neurologic disorder and recent use of psychoactive medication * Allergic to the drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The propofol requirement for pretreatment of dexmedetomidine by micro-pump until loss of consciousness | To infuse dexmedetomidine and saline completely ten minutes after |
Secondary
| Measure | Time frame |
|---|---|
| The bispectral index values when patients loss of consciousness | To infuse dexmedetomidine and saline completely ten minutes after |
Outcome results
None listed