Postoperative Pain
Conditions
Keywords
Analgesia, Dexamethasone, Levobupivacaine, Ultrasound-guided, Tranversus Abdominis
Brief summary
Dexamethasone Added to Levobupivacaine in Ultrasound-guided Tranversus Abdominis Plain Block Increased the Duration of Postoperative Analgesia After Laparoscopic Cholecystectomy.
Detailed description
In the ultrasound-guided TAP-Block with Dexamethasone group, dexamethasone is added to Levobupivacaine in Ultrasound-guided Tranversus Abdominis Plain Block after Laparoscopic Cholecystectomy. In the ultrasound-guided TAP-Block with saline group, saline is added to Levobupivacaine in Ultrasound-guided Tranversus Abdominis Plain Block , after Laparoscopic Cholecystectomy. In the ultrasound-guided TAP-Block with intravenously dexamethasone group, dexamethasone is intravenously injected , after Laparoscopic Cholecystectomy. After surgery the extension of postoperative analgesia, incident and rest pain were evaluate in each group.
Interventions
PROCEDURETAP Block and Dexamethasone
After general anesthesia and before the beginning of surgery, the ultrasound-guided is performed between the internal oblique muscle and the transversus abdominis muscle and dexamethasone is added to levopubivacaine
OTHERTAP Block and saline
After general anesthesia and before the beginning of surgery, the ultrasound-guided is performed between the internal oblique muscle and the transversus abdominis muscle and saline is added to levopubivacaine
DRUGTAP Block and Dexamethasone i.v.
After general anesthesia and before the beginning of surgery, the ultrasound-guided is performed between the internal oblique muscle and the transversus abdominis muscle and dexamethasone is injected intravenously
Sponsors
San Salvatore Hospital of L'Aquila
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients with ASA score I and II * age 18 years
Exclusion criteria
* Allergy to local anesthetics * Allergy to general anesthetics * Allergy or intolerance to acetaminophen * Severe renal impairment * Severe hepatic impairment * Congestive heart failure * Coagulation disorders * hypoprotidemia * Diabetes mellitus History * Age greater than 70 years * Age below 18 years * ASA Physical than 3 Status * Lack of informed consent * Patients unable to discernment * Intolerance to opiates * Peptic Ulcer * Abuse of alcohol and / or drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extension of analgesia, assessed in minutes after TAP block | 24 hours after surgery | After surgery, the extension of analgesia is evaluated in minutes after TAP Block, in the first 24 hours, from operating theatre discharge. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rest pain, assessed with Visual Analog Scale | 24 hours after surgery | Rest pain was assessed using Visual Analog Scale (10 steps scale, from 0 as no pain to 10 as the worst imaginable pain). |
| Incident pain, assessed with Visual Analog Scale | 24 hours after surgery | Incident pain was assessed using Visual Analog Scale (10 steps scale, from 0 as no pain to 10 as the worst imaginable pain). |
Countries
Italy
Outcome results
None listed