Intracranial Germinoma
Conditions
Brief summary
The purpose of this study is to evaluate the outcome of intracranial germinoma treated with chemotherapy plus reduced radiotherapy.
Detailed description
Treatment outcome of intracranial germinoma is excellent with radiotherapy/chemotherapy. However, late sequelae are unavoidable especially with craniospinal irradiation, and various efforts have been done to reduce the dose and extent of radiotherapy. In this study, chemotherapy and further reduced dose of radiotherapy will be used to minimize the late sequelae in the patients with intracranial germinoma.
Interventions
DRUGCarboplatin
DRUGEtoposide
DRUGCyclophosphamide
DRUGBleomycin
RADIATIONReduced dose of radiotherapy
Sponsors
Samsung Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
3 Years to 30 Years
Healthy volunteers
No
Inclusion criteria
* Patients with pathologically proven intracranial germinoma
Exclusion criteria
* Elevated serum/cerebrospinal fluid alpha-feto protein * Patients with organ dysfunction as follows (creatinine elevation, ejection fraction, liver function test \> CTCAE grade 2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of late sequelae | Up to 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Rate of event free survival | Up to 5 years |
Countries
South Korea
Contacts
Primary ContactKi Woong Sung, MD, PhD
Outcome results
None listed