Glioblastoma Multiforme, Glioma
Conditions
Brief summary
Temozolomide (TMZ) is the chemotherapy drug approved by the FDA to increase survival in glioblastoma (GBM) patients beyond surgical resection and radiation therapy alone. Give its activity in astrocytomas, TMZ is commonly used in grade III anaplastic astrocytoma (AA) as well. Both grade III AA and grade IV GBM are high grade gliomas (HGG). The short half-life of this drug and known oscillations in DNA damage repair make it an ideal candidate for chronotherapy. Chronotherapy is the improvement of treatment outcomes by minimizing treatment toxicity and maximizing efficacy through delivery of a medication according to the timing of biological rhythms within a patient. Chronotherapy has improved outcomes through the reduction of side effects and increase in anti-tumor activity for a variety of cancers, but has never been applied to the treatment of gliomas. Based on the preliminary preclinical data for chronotherapeutic TMZ treatment of intracranial glioma xenografts and the success of chronotherapy in the treatment of other cancers, the investigators hypothesize that the timing of TMZ treatment will alter its efficacy and toxicity.
Interventions
DRUGTemozolomide
-Given standard of care
OTHERFunctional Assessment of Cancer Therapy - Brain
* 23-item questionnaire that can be completed in 5 to 10 minutes with little or no assistance in patients who are not neurologically incapacitated. This brain subscale is usually used along with the core (general) questionnaire \[2\] that includes 27 items. * Patients rate all 5 items using a five-point Likert scale ranging from 0 not at all to 4 very much. Overall, higher ratings suggest higher QOL. Items are totaled to produce the following subscales, along with an overall QOL score: physical well-being (7 items); social/family well-being (7 items); emotional well-being (6 items); functional well-being (7 items); and concerns relevant to patients with brain tumors (23 items) * The sleep portion of this questionnaire consists of 17 questions about sleeping patterns and the ability to rate severity of insomnia.
OTHERActTrust Condor Instrument Watch
-Will be required to wear 24 hours per day and will only be removed at specified data collection time points
Sponsors
Washington University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Newly diagnosed and recurrent high grade gliomas (WHO grades III & IV) and high risk WHO grade II gliomas who are to begin treatment with monthly high dose temozolomide therapy. * Scheduled to receive adjuvant temozolomide therapy after having completed concurrent temozolomide and radiation therapy. * At least 18 years of age. * Karnofsky performance status ≥ 60% * Ability to understand and willingness to sign an IRB approved written informed consent document
Exclusion criteria
. -Pregnant and/or breastfeeding. Women of childbearing potential must have a negative pregnancy test within 14 days of study entry.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of Patient Treatment Compliance as Measured by Number of Participants Who Were at Least 80% Compliance With Assigned Administration Time | Through completion of treatment (median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles) | Compliance is defined as no more than one of five doses of temozolomide per cycle taken outside of the assigned administration time. |
| Duration of Response | Through completion of follow-up (estimated to be 30 months) | * Response and progression will be evaluated in this study using the updated response assessment criteria for high-grade gliomas: Response Assessment in Neuro-Oncology (RANO) working group guideline \[JCO 28(11): 1963-1972, 2010\]. * The duration of overall response is measured from the time measurement criteria are met for complete response (CR) or partial response (PR) (whichever is first recorded) until the first date that recurrent or progressive disease is objectively documented (taking as reference for progressive disease the smallest measurements recorded since the treatment started). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)) | 7-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range is 0-28. A higher score indicates a lower physical well-being quality of life. |
| Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)) | 7-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range 0-28. A higher score indicates a higher social/family well-being quality of life. |
| Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)) | 6-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range 0-24. A higher score indicates a lower emotional well-being quality of life. |
| Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)) | 7-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range 0-28. A higher score indicates a higher emotional well-being quality of life. |
| Median Progression-free Survival (PFS) | Through completion of follow-up (median length of follow-up 568.5 days, full range 1-1134 days) | PFS is defined as the duration of time from start of treatment to time of progression or death, whichever occurs first. |
| Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)) | Sleep Questionnaire - 1 yes/no question of do you have problems getting to sleep or staying asleep? |
| Mean Circadian Amplitude | From start of treatment through 2 months after end of treatment (median length 100 days, full range 78-240 days) | * The ActTrust Condor Instrument watches are wrist actimetry/accelerometers. Patients will wear an accelerometer on their wrist to measure activity level during the day and at night until two months after the end of treatment. * Circadian amplitude, refers to the difference between the highest and lowest points of a circadian rhythm over a 24-hour cycle, is typically measured in the units of the rhythm being quantified. * The circadian mean amplitude was calculated per day for each patient with the mean and standard deviation reported across all days for each individual patient. |
| Mean Sleep Regularity Index (SRI) | From start of treatment through 2 months after end of treatment (median length 100 days, full range 78-240 days) | * The ActTrust Condor Instrument watches are wrist actimetry/accelerometers. Patients will wear an accelerometer on their wrist to measure activity level during the day and at night until two months after the end of treatment. * Sleep regularity index (SRI) is the probability of being at rest, calculated per day for each patient. An SRI closer to 0 indicates irregular sleep patterns (i.e., more variable day to day), while values closer to 1 indicate regular sleep patterns. The SRI index scale is 0\ 1. * The SRI was calculated per day for each patient with the mean and standard deviation reported across all days for each individual patient. |
| Median Overall Survival | Through completion of follow-up (median length of follow-up 568.5 days, full range 1-1134 days) | — |
| Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Through completion of treatment (median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles) | * Lymphopenia grade 3 is \<500-200/mm\^3 and grade 4 is \<200/mm\^3 * Leukopenia grade 3 is \<2000-1000/mm\^3 and grade 4 is \<1000/mm\^3 * Neutropenia grade 3 is \<1000-500/mm\^3 and grade 4 is \<500/mm\^3 * Thrombocytopenia grade 3 is \<50,000-25,000/mm\^3 and grade 4 is \<25,000/mm\^3 * Anemia grade 3 is \<8.0-6.5 g/dL and grade 4 is \<6.5 g/dL |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Arm 1: Temozolomide Morning -Temozolomide will be given as per standard of care. Typical dosing is 150 to 200 mg/m\^2 on Days 1 through 5 of a 28-day treatment cycle. Patients will be randomized to take their temozolomide doses in the morning (before 10:00). | 22 |
| Arm 2: Temozolomide Evening -Temozolomide will be given as per standard of care. Typical dosing is 150 to 200 mg/m2 on Days 1 through 5 of a 28-day treatment cycle. Patients will be randomized to take their temozolomide doses in the evening (after 20:00). | 20 |
| Total | 42 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Adverse Event | 1 | 2 |
| Overall Study | Hospice | 0 | 1 |
| Overall Study | Lack of Efficacy | 1 | 1 |
| Overall Study | Withdrawal by Subject | 3 | 1 |
Baseline characteristics
| Characteristic | Arm 1: Temozolomide Morning | Total | Arm 2: Temozolomide Evening |
|---|---|---|---|
| Age, Continuous | 58.59 years STANDARD_DEVIATION 12.35 | 55.95 years STANDARD_DEVIATION 15.11 | 53.05 years STANDARD_DEVIATION 17.52 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 1 Participants | 2 Participants | 1 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 21 Participants | 39 Participants | 18 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants | 1 Participants | 1 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Black or African American | 2 Participants | 2 Participants | 0 Participants |
| Race (NIH/OMB) More than one race | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 1 Participants | 1 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 1 Participants | 2 Participants | 1 Participants |
| Race (NIH/OMB) White | 19 Participants | 37 Participants | 18 Participants |
| Region of Enrollment United States | 22 participants | 42 participants | 20 participants |
| Sex: Female, Male Female | 12 Participants | 18 Participants | 6 Participants |
| Sex: Female, Male Male | 10 Participants | 24 Participants | 14 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 7 / 22 | 6 / 20 |
| other Total, other adverse events | 4 / 22 | 1 / 20 |
| serious Total, serious adverse events | 6 / 22 | 5 / 20 |
Outcome results
Primary
Duration of Response
* Response and progression will be evaluated in this study using the updated response assessment criteria for high-grade gliomas: Response Assessment in Neuro-Oncology (RANO) working group guideline \[JCO 28(11): 1963-1972, 2010\]. * The duration of overall response is measured from the time measurement criteria are met for complete response (CR) or partial response (PR) (whichever is first recorded) until the first date that recurrent or progressive disease is objectively documented (taking as reference for progressive disease the smallest measurements recorded since the treatment started).
Time frame: Through completion of follow-up (estimated to be 30 months)
Population: Data was not collected for this outcome measure. Duration of response was never listed as an objective in the protocol; however it was erroneously mentioned in the statistical analysis section of the protocol and therefore was listed as a primary outcome measure in error as well.
Primary
Feasibility of Patient Treatment Compliance as Measured by Number of Participants Who Were at Least 80% Compliance With Assigned Administration Time
Compliance is defined as no more than one of five doses of temozolomide per cycle taken outside of the assigned administration time.
Time frame: Through completion of treatment (median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)
Population: Patients who received one full cycle of TMZ are evaluable for this outcome measure.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Arm 1: Temozolomide Morning | Feasibility of Patient Treatment Compliance as Measured by Number of Participants Who Were at Least 80% Compliance With Assigned Administration Time | 17 Participants |
| Arm 2: Temozolomide Evening | Feasibility of Patient Treatment Compliance as Measured by Number of Participants Who Were at Least 80% Compliance With Assigned Administration Time | 15 Participants |
Secondary
Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score
6-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range 0-24. A higher score indicates a lower emotional well-being quality of life.
Time frame: Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles))
Population: The number analyzed for each timepoint may be different from the overall number of participants analyzed if any participant did not complete the questionnaire at that time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 7 | 7.29 score on a scale | Standard Deviation 2.56 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 3 | 6.63 score on a scale | Standard Deviation 3.48 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 8 | 5.50 score on a scale | Standard Deviation 3.15 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Baseline | 6.72 score on a scale | Standard Deviation 3.72 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 9 | 7.33 score on a scale | Standard Deviation 2.73 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 4 | 7.04 score on a scale | Standard Deviation 3.25 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 10 | 6.08 score on a scale | Standard Deviation 3.58 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 2 | 6.06 score on a scale | Standard Deviation 4.82 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 11 | 8.60 score on a scale | Standard Deviation 3.21 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 5 | 6.68 score on a scale | Standard Deviation 1.82 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 12 | 6.25 score on a scale | Standard Deviation 2.22 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 1 | 6.69 score on a scale | Standard Deviation 4.69 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | End of treatment | 5.44 score on a scale | Standard Deviation 3.22 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 6 | 6.23 score on a scale | Standard Deviation 3.45 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | End of treatment | 5.62 score on a scale | Standard Deviation 2.4 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Baseline | 7.60 score on a scale | Standard Deviation 3.19 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 1 | 8.11 score on a scale | Standard Deviation 2.85 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 2 | 6.77 score on a scale | Standard Deviation 2.1 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 3 | 6.92 score on a scale | Standard Deviation 2.14 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 4 | 5.47 score on a scale | Standard Deviation 2.7 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 5 | 5.36 score on a scale | Standard Deviation 2.01 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 7 | 5.14 score on a scale | Standard Deviation 2.73 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 8 | 5.67 score on a scale | Standard Deviation 1.51 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 9 | 4.70 score on a scale | Standard Deviation 1.99 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 10 | 5.25 score on a scale | Standard Deviation 1.71 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 11 | 5.50 score on a scale | Standard Deviation 1.91 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 12 | 8.33 score on a scale | Standard Deviation 1.53 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Emotional Well-being Score | Cycle 6 | 5.57 score on a scale | Standard Deviation 1.51 |
Secondary
Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score
7-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range 0-28. A higher score indicates a higher emotional well-being quality of life.
Time frame: Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles))
Population: The number analyzed for each timepoint may be different from the overall number of participants analyzed if any participant did not complete the questionnaire at that time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 10 | 14.58 score on a scale | Standard Deviation 8.48 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 7 | 18.71 score on a scale | Standard Deviation 6.34 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 3 | 16.37 score on a scale | Standard Deviation 5.59 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 8 | 18.50 score on a scale | Standard Deviation 7.18 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 1 | 18.71 score on a scale | Standard Deviation 7.09 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 9 | 17.00 score on a scale | Standard Deviation 5.66 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 4 | 17.75 score on a scale | Standard Deviation 6.82 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Baseline | 18.19 score on a scale | Standard Deviation 6.39 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 11 | 18.80 score on a scale | Standard Deviation 4.6 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 2 | 15.94 score on a scale | Standard Deviation 8.68 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 12 | 17.50 score on a scale | Standard Deviation 6.24 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 6 | 18.64 score on a scale | Standard Deviation 7.66 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | End of treatment | 17.13 score on a scale | Standard Deviation 8.24 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 5 | 17.32 score on a scale | Standard Deviation 7.23 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | End of treatment | 18.54 score on a scale | Standard Deviation 6.73 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Baseline | 16.35 score on a scale | Standard Deviation 7.06 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 1 | 15.89 score on a scale | Standard Deviation 7.59 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 2 | 16.11 score on a scale | Standard Deviation 7.17 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 3 | 17.69 score on a scale | Standard Deviation 5.86 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 4 | 18.78 score on a scale | Standard Deviation 6.93 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 5 | 19.27 score on a scale | Standard Deviation 7.86 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 6 | 20.00 score on a scale | Standard Deviation 7.28 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 7 | 23.57 score on a scale | Standard Deviation 5.77 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 8 | 21.00 score on a scale | Standard Deviation 5.59 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 9 | 20.00 score on a scale | Standard Deviation 6.89 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 10 | 25.00 score on a scale | Standard Deviation 3.16 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 11 | 23.50 score on a scale | Standard Deviation 4.12 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Functional Well-being Score | Cycle 12 | 23.33 score on a scale | Standard Deviation 6.43 |
Secondary
Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score
7-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range is 0-28. A higher score indicates a lower physical well-being quality of life.
Time frame: Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles))
Population: The number analyzed for each timepoint may be different from the overall number of participants analyzed if any participant did not complete the questionnaire at that time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Baseline | 6.23 score on a scale | Standard Deviation 4.17 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 1 | 5.78 score on a scale | Standard Deviation 4.96 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 2 | 7.66 score on a scale | Standard Deviation 6.92 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 3 | 7.33 score on a scale | Standard Deviation 5.67 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 4 | 6.18 score on a scale | Standard Deviation 4.09 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 5 | 5.27 score on a scale | Standard Deviation 4.54 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 6 | 4.64 score on a scale | Standard Deviation 3.44 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 7 | 4.71 score on a scale | Standard Deviation 4.19 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 8 | 3.83 score on a scale | Standard Deviation 4.36 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 9 | 6.83 score on a scale | Standard Deviation 4.62 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 10 | 5.35 score on a scale | Standard Deviation 4.65 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 11 | 5.60 score on a scale | Standard Deviation 5.59 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 12 | 4.50 score on a scale | Standard Deviation 5.92 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | End of treatment | 5.19 score on a scale | Standard Deviation 4.58 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 10 | 2.00 score on a scale | Standard Deviation 1.63 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Baseline | 4.80 score on a scale | Standard Deviation 4.27 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 7 | 3.00 score on a scale | Standard Deviation 2.71 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 1 | 4.00 score on a scale | Standard Deviation 2.83 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 12 | 2.00 score on a scale | Standard Deviation 1 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 2 | 8.32 score on a scale | Standard Deviation 5.65 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 8 | 3.50 score on a scale | Standard Deviation 4.14 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 3 | 7.69 score on a scale | Standard Deviation 5.31 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 11 | 2.00 score on a scale | Standard Deviation 1.41 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 4 | 5.53 score on a scale | Standard Deviation 4.74 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 9 | 4.00 score on a scale | Standard Deviation 4.64 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 5 | 7.03 score on a scale | Standard Deviation 5.8 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | End of treatment | 5.46 score on a scale | Standard Deviation 3.82 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Physical Well-being Score | Cycle 6 | 5.71 score on a scale | Standard Deviation 5.59 |
Secondary
Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score
7-item questionnaire measuring over the past 7 days. Answers range from 0=not at all to 4=very much. Total score range 0-28. A higher score indicates a higher social/family well-being quality of life.
Time frame: Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles))
Population: The number analyzed for each timepoint may be different from the overall number of participants analyzed if any participant did not complete the questionnaire at that time point.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 2 | 22.45 score on a scale | Standard Deviation 7.32 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 7 | 20.95 score on a scale | Standard Deviation 6.31 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Baseline | 24.10 score on a scale | Standard Deviation 4.09 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 4 | 23.21 score on a scale | Standard Deviation 3.71 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 9 | 22.25 score on a scale | Standard Deviation 4.4 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 1 | 24.29 score on a scale | Standard Deviation 4.13 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 10 | 22.94 score on a scale | Standard Deviation 5.56 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 5 | 22.91 score on a scale | Standard Deviation 4.72 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 11 | 23.77 score on a scale | Standard Deviation 3.09 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 8 | 22.78 score on a scale | Standard Deviation 3.15 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 12 | 24.00 score on a scale | Standard Deviation 2.94 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 6 | 22.44 score on a scale | Standard Deviation 5.41 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | End of treatment | 21.95 score on a scale | Standard Deviation 4.21 |
| Arm 1: Temozolomide Morning | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 3 | 23.14 score on a scale | Standard Deviation 5.93 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | End of treatment | 22.73 score on a scale | Standard Deviation 4.38 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Baseline | 22.94 score on a scale | Standard Deviation 3.98 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 1 | 22.59 score on a scale | Standard Deviation 4.52 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 2 | 23.12 score on a scale | Standard Deviation 4.18 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 3 | 22.26 score on a scale | Standard Deviation 5.67 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 4 | 23.06 score on a scale | Standard Deviation 4.78 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 5 | 22.30 score on a scale | Standard Deviation 5.59 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 6 | 23.05 score on a scale | Standard Deviation 5.13 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 7 | 24.86 score on a scale | Standard Deviation 2.86 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 8 | 22.47 score on a scale | Standard Deviation 4.26 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 9 | 22.52 score on a scale | Standard Deviation 4.92 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 10 | 23.25 score on a scale | Standard Deviation 2.63 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 11 | 26.08 score on a scale | Standard Deviation 2.01 |
| Arm 2: Temozolomide Evening | Change in Quality of Life as Measured by FACT-Br Score - Social/Family Well-being Score | Cycle 12 | 24.39 score on a scale | Standard Deviation 1.99 |
Secondary
Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening
Sleep Questionnaire - 1 yes/no question of do you have problems getting to sleep or staying asleep?
Time frame: Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles))
Population: Sleep questionnaires were only collected on 6 patients in each arm. If one of the 12 patients didn't complete a sleep questionnaire then they are not included in that timepoint.
| Arm | Measure | Group | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 7 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 2 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 7 | No | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 4 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 8 | Yes | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Baseline | No | 4 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 8 | No | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 4 | No | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 9 | Yes | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 2 | No | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 9 | No | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 5 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 10 | Yes | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 1 | No | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 10 | No | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 5 | No | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 11 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 3 | Yes | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 11 | No | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 6 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 12 | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 1 | Yes | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 12 | No | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 6 | No | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | End of Treatment | Yes | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 3 | No | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | End of Treatment | No | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Baseline | Yes | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | End of Treatment | No | 6 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Baseline | Yes | 4 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Baseline | No | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 1 | Yes | 3 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 1 | No | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 2 | Yes | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 2 | No | 3 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 3 | Yes | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 3 | No | 3 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 4 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 4 | No | 5 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 5 | Yes | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 5 | No | 4 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 6 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 6 | No | 3 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 7 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 7 | No | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 8 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 8 | No | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 9 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 9 | No | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 10 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 10 | No | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 11 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 11 | No | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 12 | Yes | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Cycle 12 | No | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | End of Treatment | Yes | 0 Participants |
Secondary
Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening
\- Sleep Questionnaire: * Difficulty falling asleep/difficulty staying asleep/problem waking up too early: Answers range from 0=none, mild=1, moderate=2, severe=3, very=4. * How satisfied or dissatisfied are you with your current sleeping pattern question: Answers range from 0=very satisfied to 4=very dissatisfied. * To what extent do you consider your sleep problem to interfere with your daily functioning question: Answers range from 0=not at all interfering, 1=a little, 2=somewhat, 3=much, 4=very much interfering. * How noticeable to others do you think your sleep problem is in terms of impairing the quality of your life question: Answers range from 0=not at all noticeable, 1=barely, 2 = somewhat, 3 =much, 4=very noticeable. * How worried or distressed are you about your current sleep problem question: Answers range from 0=not at all=0, 1=a little, 2=somewhat, 3=much, 4=very much.
Time frame: Baseline, beginning of each cycle (each cycle is 28 days), and 1 month after completion of treatment (up to 13 months, median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles))
Population: Sleep questionnaires were only collected on 6 patients in each arm. If one of the 12 patients didn't complete a sleep questionnaire then they are not included in that timepoint.
| Arm | Measure | Group | Category | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 2 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 3 Participants |
| Arm 1: Temozolomide Morning | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 4 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 3 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 3 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 1 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 2 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 4 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 3 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 4 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 3 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 5 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 3 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 4 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 2 Participants |
| Arm 2: Temozolomide Evening CYCLE 6 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 7 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 8 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 9 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 10 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 11 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 1 Participants |
| Arm 1: Temozolomide Morning CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 1 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening CYCLE 12 | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 3 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 2 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 3 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 1 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 2 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 2 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 2 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 1: Temozolomide Morning END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 1 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 2 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 1 | 3 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 2 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 1 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 2 | 1 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 0 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 1 | 3 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 2 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 1 | 3 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 3 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 4 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 0 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 0 | 5 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 1 | 4 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 3 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 0 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | To what extent do you consider your sleep problem to interfere with your daily functioning? | 0 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 1 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 1 | 1 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 2 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How satisfied or dissatisfied are you with your current sleeping pattern? | 3 | 2 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How worried or distressed are you about your current sleep problem? | 2 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty falling asleep | 3 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | How noticeable to others is your sleep problem is in terms of impairing the quality of your life | 3 | 0 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Problem waking up too early | 0 | 3 Participants |
| Arm 2: Temozolomide Evening END OF TREATMENT | Comparison of Sleep Questionnaire in Participants Receiving Temozolomide in the Morning Versus Participants Receiving Temozolomide in the Evening | Difficulty staying asleep | 0 | 2 Participants |
Secondary
Mean Circadian Amplitude
* The ActTrust Condor Instrument watches are wrist actimetry/accelerometers. Patients will wear an accelerometer on their wrist to measure activity level during the day and at night until two months after the end of treatment. * Circadian amplitude, refers to the difference between the highest and lowest points of a circadian rhythm over a 24-hour cycle, is typically measured in the units of the rhythm being quantified. * The circadian mean amplitude was calculated per day for each patient with the mean and standard deviation reported across all days for each individual patient.
Time frame: From start of treatment through 2 months after end of treatment (median length 100 days, full range 78-240 days)
Population: Actimetry data was only collected on 6 participants.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Mean Circadian Amplitude | AM Patient #1 | 0.78 counts/minute | Standard Deviation 0.02 |
| Arm 1: Temozolomide Morning | Mean Circadian Amplitude | AM Patient #2 | 0.78 counts/minute | Standard Deviation 0.01 |
| Arm 2: Temozolomide Evening | Mean Circadian Amplitude | PM Patient #1 | 0.81 counts/minute | Standard Deviation 0.01 |
| Arm 2: Temozolomide Evening | Mean Circadian Amplitude | PM Patient #2 | 0.78 counts/minute | Standard Deviation 0.01 |
| Arm 2: Temozolomide Evening | Mean Circadian Amplitude | PM Patient #3 | 0.77 counts/minute | Standard Deviation 0.02 |
| Arm 2: Temozolomide Evening | Mean Circadian Amplitude | PM Patient #4 | 0.81 counts/minute | Standard Deviation 0.01 |
Secondary
Mean Sleep Regularity Index (SRI)
* The ActTrust Condor Instrument watches are wrist actimetry/accelerometers. Patients will wear an accelerometer on their wrist to measure activity level during the day and at night until two months after the end of treatment. * Sleep regularity index (SRI) is the probability of being at rest, calculated per day for each patient. An SRI closer to 0 indicates irregular sleep patterns (i.e., more variable day to day), while values closer to 1 indicate regular sleep patterns. The SRI index scale is 0\ 1. * The SRI was calculated per day for each patient with the mean and standard deviation reported across all days for each individual patient.
Time frame: From start of treatment through 2 months after end of treatment (median length 100 days, full range 78-240 days)
Population: Actimetry data was only collected on 6 participants.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Arm 1: Temozolomide Morning | Mean Sleep Regularity Index (SRI) | AM Patient #1 | 0.70 units on a scale | Standard Deviation 0.09 |
| Arm 1: Temozolomide Morning | Mean Sleep Regularity Index (SRI) | AM Patient #2 | 0.79 units on a scale | Standard Deviation 0.8 |
| Arm 2: Temozolomide Evening | Mean Sleep Regularity Index (SRI) | PM Patient #1 | 0.82 units on a scale | Standard Deviation 0.09 |
| Arm 2: Temozolomide Evening | Mean Sleep Regularity Index (SRI) | PM Patient #2 | 0.69 units on a scale | Standard Deviation 0.1 |
| Arm 2: Temozolomide Evening | Mean Sleep Regularity Index (SRI) | PM Patient #3 | 0.68 units on a scale | Standard Deviation 0.08 |
| Arm 2: Temozolomide Evening | Mean Sleep Regularity Index (SRI) | PM Patient #4 | 0.82 units on a scale | Standard Deviation 0.11 |
Secondary
Median Overall Survival
Time frame: Through completion of follow-up (median length of follow-up 568.5 days, full range 1-1134 days)
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Arm 1: Temozolomide Morning | Median Overall Survival | 26.9739 months |
| Arm 2: Temozolomide Evening | Median Overall Survival | 17.1831 months |
Secondary
Median Progression-free Survival (PFS)
PFS is defined as the duration of time from start of treatment to time of progression or death, whichever occurs first.
Time frame: Through completion of follow-up (median length of follow-up 568.5 days, full range 1-1134 days)
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Arm 1: Temozolomide Morning | Median Progression-free Survival (PFS) | 11.5978 months |
| Arm 2: Temozolomide Evening | Median Progression-free Survival (PFS) | 8.1809 months |
Secondary
Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws
* Lymphopenia grade 3 is \<500-200/mm\^3 and grade 4 is \<200/mm\^3 * Leukopenia grade 3 is \<2000-1000/mm\^3 and grade 4 is \<1000/mm\^3 * Neutropenia grade 3 is \<1000-500/mm\^3 and grade 4 is \<500/mm\^3 * Thrombocytopenia grade 3 is \<50,000-25,000/mm\^3 and grade 4 is \<25,000/mm\^3 * Anemia grade 3 is \<8.0-6.5 g/dL and grade 4 is \<6.5 g/dL
Time frame: Through completion of treatment (median length of treatment 6 cycles - each cycle is 28 days (full range 2-12 cycles)
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Arm 1: Temozolomide Morning | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Thrombocytopenia | 1 Participants |
| Arm 1: Temozolomide Morning | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Anemia | 1 Participants |
| Arm 1: Temozolomide Morning | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Neutropenia | 0 Participants |
| Arm 1: Temozolomide Morning | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Leukopenia | 1 Participants |
| Arm 1: Temozolomide Morning | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Lymphopenia | 2 Participants |
| Arm 2: Temozolomide Evening | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Leukopenia | 0 Participants |
| Arm 2: Temozolomide Evening | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Lymphopenia | 0 Participants |
| Arm 2: Temozolomide Evening | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Thrombocytopenia | 0 Participants |
| Arm 2: Temozolomide Evening | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Neutropenia | 1 Participants |
| Arm 2: Temozolomide Evening | Number of Patients Experiencing Grade 3 or 4 Lymphopenia, Thrombocytopenia, Neutropenia, Leukopenia, and Anemia in Each Group as Measured by Standard Blood Draws | Anemia | 0 Participants |