Cannabis
Conditions
Brief summary
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Interventions
DRUGTHC
Active THC (0.015mg/kg) administered over 10 minutes
DRUGPlacebo
Control: small amount of alcohol (quarter teaspoon), with no THC over 10 minutes
Sponsors
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* at least one lifetime exposure to cannabis * good physical and mental health
Exclusion criteria
* cannabis naive individuals * major current or recent stressors * taking estrogen supplements or oral contraceptive pills (for women)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rewarding Effects measured by Visual Analog Scale (VAS) | changes in high assessed over the following timepoints: baseline, +10, +80, and +200 minutes after THC infusion begins | subjective measure of THC induced high |
| Verbal Learning: measured by Rey Auditory Verbal Learning Test (AVLT) | 25 minutes after THC infusion begins | measured as delay recall on the AVLT |
Countries
United States
Contacts
Primary ContactChristina Luddy, BS
Outcome results
None listed