Navigation and Free Recall in Chronically Implanted Humans

Memory, Epilepsy and Brain Stimulation: Oscillatory Patterns During Real-world Navigation and Free Recall in Chronically Implanted Humans

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02781129

Enrollment

Registered

2016-05-24

Start date

2016-05-31

Completion date

2025-05-31

Last updated

2025-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Keywords

Memory, Responsive Neurostimulator System

Brief summary

This study is designed to identify brain activity associated with good memory in subjects with a chronically implanted RNS® device and to study the effects of therapeutic stimulation for epilepsy on memory. This will be accomplished through analysis of ECoG data collected during memory encoding for short and long-term free recall as well as during navigation tasks.

Interventions

OTHERelectrical stimulation

Stimulation applied will be within parameters commonly used for the treatment of epilepsy during periods of encoding, recall, and memory maintenance .

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* able to give informed consent * 18 years of age or older * Diagnosis of epilepsy * Implanted RNS® device and receiving therapeutic stimulation for epilepsy. * Capable of completing experimental tasks in the judgment of the Principal Investigator

Exclusion criteria

* RNS® Neurostimulator implanted within 3 months of experimental tasks.

Design outcomes

Primary

Measure	Time frame	Description
Proportion of words recalled with and without stimulation.	30 days	This study is designed to study the effects of therapeutic stimulation for epilepsy on memory. This outcome will be assessed by free recall language and memory tasks.

Secondary

Measure	Time frame	Description
Changes in the power spectrum of ECoG data with an increase of recalled words.	30 days	This study is designed to identify brain activity associated with good memory in subjects with a chronically implanted RNS® device. This outcome will be assessed by free recall language and memory tasks.
Proportion of words recalled during times of interictal activity.	30 days	This study is designed to investigate the effects of IEDs on spatial, long-term, and short-term memory. This will be assessed by free recall language and memory tasks.
Proportion of navigation challenges recalled successfully with and without stimulation.	30 days	This outcome will be assessed by real-world and virtual navigation tasks.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026