Atrial Fibrillation
Conditions
Keywords
Atrial Fibrillation
Brief summary
The aim of the study is to examine the effect of RIPC on physiological parameters in non-valvular paroxysmal atrial fibrillation. Furthermore the study will provide a unique bio-date base for further analysis of molecular and genetic mechanisms responsible for observed results. The potential effect of RIPC on AF inducibility and/or prothrombotic activity might be implemented as additional treatment component to reduce AF burden and minimize thromboembolic risk. Interim Analysis will be done after 73 patients.
Interventions
PROCEDURERemote ischemic preconditioning (RIPC)
RIPC will be induced by the application of 3 short episodes (5 minutes) of forearm ischemia by cuff sphygmomanometer inflation separated by 5 minutes of reperfusion.
PROCEDUREsham-intervention
In the control group the cuff will be inflated for 3 times at 10 mm Hg for 5 minutes with 5-minute intervals
Sponsors
Jedrzej Kosiuk
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* planned invasive Atrial Fibrillation ablation
Exclusion criteria
* AF in ECG at Admission * history of AF ablation * age \<18 * pregnancy * neoplastic disorders * acute or systemic inflammation, autoimmune diseases * documented atrial flutter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inducibility of Atrial Fibrillation by high-rate pacing of 20 s | during the Atrial Fibrillation Ablation procedure |
| sustainability of Atrial Fibrillation measured in seconds | during the Atrial Fibrillation Ablation procedure |
Countries
Germany
Contacts
Primary ContactJedrzej Kosiuk, MD
Outcome results
None listed