Carcinoma, Hepatocellular, Hepatitis B
Conditions
Keywords
vitamin D treatment, chronic hepatitis B
Brief summary
The purpose of this study is to determine whether vitamin D is effective in the prevention of hepatocellular carcinoma in those patients with chronic hepatitis B.
Detailed description
Potential participants will be identified from the follow-up cohort of chronic hepatitis B in the third Affiliated Hospital of Sun Yat-sen University (3rd SYSU). The hepatologists at the 3rd SYSU's Infectious Disease Institute will ask each potential participant if she/he is interested in participating. If the patient expresses an interest in the study, one of the researchers will meet with the patient when he/she is at the 3rd SYSU for a regular appointment and will describe the study to the potential participant. If a patient continues to be interested in participating, she/he will be given a copy of the review board approved consent document to read. The consent document will be used as a guide for explaining the study in detail to the patient. The participant allocated to the experimental group will be contacted by one of the investigators on the research team and instructed to begin taking 2 tablets per day (800 IU total) of vitamin D3 besides their regular anti-virus treatment. Those patients allocated in the control group will be informed that they are not to take any vitamin D3 and they will be followed as controls for this study. The researcher will investigate general treatment benefits and the potential to reduce the development of Hepatocellular carcinoma (HCC), also known as liver cancer. Improvement of treatment benefits will be determined by interviews with patients, the level of HBsAg and HBeAg, the development of liver fibrosis and evidence of HCC on routine imaging.
Interventions
DRUGVitamin D3
Participants with chronic hepatitis B will take 800 IU of vitamin D3 per day by mouth besides the anti-virus treatment with nucleos(t)ide medicine
Sponsors
Third Affiliated Hospital, Sun Yat-Sen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* All subjects between the ages of 18 and 70 with chronic hepatitis B and under the oral anti-virus treatment followed at the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, will be offered entry into this study. The diagnosis of chronic Hepatitis B will be based on that they had been positive for hepatitis B surface antigen (HBsAg) for at least six months, and were positive for HBeAg or negative for HBeAg with detectable HBV DNA at screening. * No evidence of HCC on entry imaging study. * Model for End Stage Liver Disease (MELD) score under 22 (a MELD score over 22 would predict a 3 month mortality rate of approximately 20%). * Not currently participating in another intervention study. * Not pregnant or lactating, and willing to use effective contraception during study period. * Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule. * Ability to provide written informed consent according to national/local regulations.
Exclusion criteria
* evidence of hepatocellular carcinoma within 6 months after enrollment, * a serum alanine aminotransferase level more than 10 times the upper limit of normal, * an elevated serum creatinine level, * any diagnosis of kidney stones, * a diagnosis of hyperparathyroidism or other serious disturbance of calcium metabolism in the past 5 years, * any evidence of autoimmune hepatitis, coinfection with hepatitis C or D virus or human immunodeficiency virus, * other serious concurrent illness (e.g., alcoholism, uncontrolled diabetes, or cancer), * treatment with immunomodulatory within the 6 months before screening, * treatment with any investigational drug within the 30 days before the study began.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum levels of 25-hydroxy vitamin D | at baseline, and at 6 and 12 months | Change in serum levels of 25-hydroxyvitamin D at 6 months and 12 months compared to baseline |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum creatinine | at baseline, and at 6 and 12 months | Change in serum creatinine at 6 months and at 12 months compared to baseline |
| Change in fibrosis score | at baseline, and at 6 and 12 months | Change in fibrosis score at 6 months and at 12 months compared to baseline. The investigators use Fibroscan to get the score of fibrosis. |
| Number of participants on Vitamin D treatment with adverse events | 1 year | — |
Contacts
Primary ContactYutian Chong, MD
Outcome results
None listed