Infertility Associated With Endometriosis
Conditions
Keywords
GnRH-a, endometriosis, efficiency
Brief summary
This study is a multicenter, randomized-control-trial. This study select 1184 Infertile patients associated with endometriosis diagnosed by laparoscopy surgery. Patients are going to be divided into two groups according to 1:1 ratio randomly assigned to receive GnRH-a. Cumulative pregnancy rate, end of treatment to natural pregnancy time, accept the assisted reproductive treatment rate, miscarriage rate, live birth rate will be recorded.
Interventions
DRUGGoserelin Acetate
Sponsors
Peking University People's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Infertile patients * Endometriosis I-II phase：according to Revised American Society for Reproductive Medicine classification of endometriosis: 1996 * BMI:19-28 kg/㎡ * Ovarian reserve function is normal（M2-5：bilateral antral follicles≥6 FSH：5-12U/ml）
Exclusion criteria
* Male factor causes infertility * hydrosalpinx or salpingemphraxis * Uterine malformation * Uterine cavity lesion * Contra-indications for GnRH-a * not willing to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative pregnancy rate | 18 month after surgery | Cumulative pregnancy rate of 18 month after surgery |
| Time interval between surgery and natural pregnancy | 18 month after surgery | Time interval between surgery and natural pregnancy |
| miscarriage rate | 18 month after surgery | miscarriage rate of patients who get natural pregnancy |
Outcome results
None listed