Physiology
Conditions
Brief summary
This study aims to determine the effect of acute hypnotic intake (Zolpidem) on sleep, cognitive and motor performances and on acute mountain sickness symptoms at high altitude. Healthy subjects will be evaluated on 4 occasions (twice at sea level and twice at high altitude), after hypnotic or placebo intake. Following an early wake-up (01:00), symptoms, cognitive and motor performances will be assessed to determine potential residual effects of Zolpidem within such conditions.
Interventions
DRUGZolpidem
The hypnotic will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment.
DRUGPlacebo
The placebo will be administrated orally at 22:00 in the evening before a sleep recording and an early wake-up at 01:00 for cognitive and motor assessment.
Sponsors
Centre d'Expertise sur l'Altitude EXALT
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* No sojourn above 2500 m during the past 2 months * Coffee intake \< 3 cups per day * Non-smoker
Exclusion criteria
* Respiratory, cardiovascular, metabolic or neuromuscular diseases * Psychiatric disorders * Use of hypnotics within the past year * Dependence syndrome (alcool, drugs, etc) * Severe insomnia or somnolence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive performance assessed using Simon cognitive test | 4 hours after drug/placebo intake | Simon cognitive test |
Countries
France
Outcome results
None listed