Intermittent Claudication, Peripheral Artery Disease
Conditions
Brief summary
The aim of this study was to analyze the effects of resistance exercise and training on cardiovascular function of peripheral artery disease patients.
Detailed description
Several studies have shown that strength training can promote important benefits for the cardiovascular system in healthy subjects and patients with chronic diseases. However, the effects of resistance exercise on cardiovascular function in intermittent claudication patients are unclear. In addition, it also do not know the chronic effects on cardiovascular function in these patients.
Interventions
BEHAVIORALResistance training
Resistance training exercises
BEHAVIORALControl
Stretching exercises
Sponsors
Fundação de Amparo à Ciência e Tecnologia de Pernambuco
Conselho Nacional de Desenvolvimento Científico e Tecnológico
University of Pernambuco
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Had a graded treadmill test that was limited by claudication (2 minutes) * Had an ankle brachial index \<0.90 * Had systolic blood pressure ,160 mmHg and/or diastolic blood pressure,105 mmHg * Were not performing any regular exercise program * Were not using antihypertensive medications affecting the heart rate (e.g., b-blockers and nondihydropyridine calcium channel blockers) * Were nonobese * Individuals who have not undergone bypass surgery or angioplasty least one year ago
Exclusion criteria
* Had no symptoms related to myocardial ischemia during the treadmill test * Amputation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in blood pressure | Change from baseline to 12 and 24 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Health related Quality of life | Change from baseline to 12 and 24 weeksBaseline, 12 wks and 24 wks | — |
| Change in Muscle blood flow of limbs | Change from baseline to 12 and 24 weeks | Muscle blood flow assessed with venous occlusion plethysmography |
| Change in body fat | Change from baseline to 12 and 24 weeks | — |
| Change in Walking distance | Change from baseline to 12 and 24 weeks | — |
| Change in serum glucose | Change from baseline to 12 and 24 weeks | — |
| Change in TNFalpha | Change from baseline to 12 and 24 weeks | — |
| Change in Score Short-physical performance battery | Change from baseline to 12 and 24 weeks | — |
| Change Serum Cholesterol | Change from baseline to 12 and 24 weeks | — |
Countries
Brazil
Outcome results
None listed