Predictors of Pulmonary Hypertension in Patients With Advanced Lung Diseases

Predictors and Survival in Pulmonary Hypertension Associated With Severe Lung Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02777957

Enrollment

200

Registered

2016-05-19

Start date

2008-12-31

Completion date

2023-04-30

Last updated

2020-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary Hypertension

Keywords

Echocardiography, Lung Transplantation

Brief summary

First, the aim of the study was to evaluate the usefulness of echocardiographic parameters for detecting pulmonary hypertension (PH) in patients with advanced lung disease referred for lung transplantation. Second, to assess the prevalence of PH and to identify which hemodynamic, echocardiographic, pulmonary functional test, exercise capacity and biochemical parameters (especially NT-proBNP) have an impact on survival in a cohort of patients with severe lung diseases referred for lung transplantation.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* advanced lung disease * qualification for lung transplantation * written informed consent * pulmonary capillary wedge pressure \< 15 mmHg

Exclusion criteria

* cancer, * history of idiopathic pulmonary hypertension, * primary valvular heart diseases, * coronary artery disease, * collagen vascular disease, * history or evidence of left ventricular dysfunction, * atrial fibrillation, * increased liver enzyme levels ( 3 times the upper laboratory limit), * renal dysfunction (estimated glomerular filtration rate \< 60 ml/min/1.73m2) * patients who didn't write the personal informed consent * any specific therapy for PH.

Design outcomes

Primary

Measure	Time frame
Survival after the initial right heart catheterization (RHC) measurements	1 year

Secondary

Measure	Time frame
Survival to lung transplantation or the end of the observation period after the initial right heart catheterization (RHC) measurement	3 years

Countries

Poland

Outcome results