Transplantation Infection
Conditions
Brief summary
The purpose of this work was to study the incidence, types, risk factors and causative organisms of bacterial infections in HCV Egyptian patients following Liver Transplantation. Moreover, to identify the emerging resistant strains and their proper antimicrobial therapy
Detailed description
This prospective descriptive study has been done at Tropical Medicine department in the period between January 2014 to November 2015. After the approval of the scientific and ethical committee of Ain Shams University Hospital, Patients with HCV positive end stage liver disease (ESLD) eligible for liver transplantation Ain Shams Center for Organ Transplant (ASCOT); Ain Shams University, (fulfilling the inclusion criteria) were included in the current study. Forty five patients were recruited and each one was followed-up during a period of 3 months following transplantation. Included patients were divided into 2 groups: Group 1 included patients who had a postoperative single episode of infection. Group 2 included those patients who had more than 1 episode of postoperative bacterial infection whom were further evaluated for the presence of emerging strains and/or antibiotic resistance.
Interventions
PROCEDURELiving donor liver transplantation
Sponsors
Ain Shams University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Egyptian nationality. * Accepting participation in the current study and signing a written consent form * Age between 18-60 Years, including males and females.
Exclusion criteria
* Patients who refused to be enrolled in the study. * Patients with other etiologies for end-stage liver disease (HBV, PBC…) * Patients with preoperative infections, infections within 48 h after transplantation or early post-operative death
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determine the types of early bacterial infections following LDLT, recurrent and resistant infections all were confirmed by cultures. | Within the first 90 days after the operation | Bile, abdominal drains, blood stream infection, urinary tract infection or chest infection. |
| Assessment of risk factors for occurrence of recurrent bacterial infections | The first 3 months following LDLT | Independent risk factors for infections |
Outcome results
None listed