ADPKD
Conditions
Keywords
ADPKD, total kidney volume, kidney disease
Brief summary
The objective of this study is to measure the influence of both short term water restriction and high water intake on total kidney volume, measured by Magnetic Resonance Imaging (MRI) scan in Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients.
Detailed description
Patients will be randomized to either water restriction for 3 hours or high water intake (20 ml/kg) for 1 hour. Before intervention and after intervention patients will have an MRI scan of the kidneys to measure the total kidney volume (TKV) (differentiated in cortex, medulla and cyst volume). The objective is to identify whether water restriction or high water load will change the TKV. Secondly investigators will analyze different biomarkers (aldosterone, renin, vasopressin/copeptin, urine- and blood-osmolarity) before and after the intervention.
Interventions
OTHERwater
Sponsors
Aarhus University Hospital
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ADPKD * CKD stage 1-3
Exclusion criteria
* Patients treated with diuretics * Pregnancy * Change in antihypertensive treatment \< 1 month * Any condition contraindicating MR scan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in total kidney volume | Baseline and 3 hours |
Secondary
| Measure | Time frame |
|---|---|
| Change in total cyst volume | Baseline and 3 hours |
| Change in plasma renin | Baseline and 3 hours |
| Change in plasma aldosterone | Baseline and 3 hours |
| Change in plasma copeptin | Baseline and 3 hours |
Countries
Denmark
Outcome results
None listed