Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer

Letrozole and Sequential Clomiphene to Improve the Outcome of Embryo Transfer in Polycystic Ovary Syndrome (PCOS) Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02775877

Enrollment

100

Registered

2016-05-18

Start date

2016-05-31

Completion date

2020-01-31

Last updated

2017-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female Infertility Due to Nonimplantation of Ovum

Keywords

PCOS, letrozole, clomiphene

Brief summary

The purpose of this study is to study the effects of letrozole and sequential clomiphene in ovulation and pregnancy in PCOS patients.

Detailed description

To evaluate the efficacy of letrozole and clomiphene in PCOS patients is important,especially in resistent PCOS patients. Although most medications prove the effectiveness of letrozole and clomiphene,the subjects of letrozole and sequential clomiphene in PCOS patients are rarely.The trial may provide further basis for this medication in PCOS patients in ovulation. If the medication demonstrates efficacy, the method would help the patients with PCOS to deal with the problem of infertility.

Interventions

DRUGLetrozole

DRUGclomiphene

DRUGHMG

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 38 Years

Healthy volunteers

Yes

Inclusion criteria

* Women with PCOS

Exclusion criteria

* •Women more than 38 years or less than 20 years * With infectious diseases or endocrine diseases * Who refuse to participate in the experiment

Design outcomes

Primary

Measure	Time frame	Description
live birth rate	3 years	The event that a FETUS is born alive with heartbeats or RESPIRATION

Secondary

Measure	Time frame	Description
clinical pregnancy rate	3 years	The ratio of the number of conceptions (CONCEPTION) including Live BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
multiple pregnancies	3 years	The condition of carrying two or more FETUSES.
miscarriage	3 years	Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
mature follic	1 month	The diameter of follic more than 18mm is the mature follic

Countries

China

Contacts

Primary ContactLi He

qiufengyi0505@163.com17710379833

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026