Epilepsy
Conditions
Keywords
epilepsy, dynamic cerebral autoregulation
Brief summary
The purpose of this study is to determine whether patients with epilepsy exhibiting impaired dCA, which may contribute to subsequent stroke.
Detailed description
The relationship between epileptic seizures and cerebrovascular disease is complex, ranging from mechanisms to clinical manifestation. Stroke is one of the most common causes of epilepsy in adulthood. It was also reported that patients with epilepsy exhibited a higher risk of stroke. But its potential mechanism was never fully understood. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral bold flow, has been proved to be critical for the occurrence ,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that impaired dCA play a role in epilepsy and subsequent stroke.
Interventions
None listed
Sponsors
Yi Yang
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* patients with epilepsy, as diagnosed by EEG
Exclusion criteria
* patients with status epilepticus * intracranial and/or extracranial major vascular stenosis/occlusion diagnosed by a transcranial Doppler (EMS-9PB, Delica, China) and carotid ultrasound (IU22, Phillips, Andover, MA) * a prior symptomatic cerebral vascular disease * a history of hypertension, cardiovascular disease, diabetes, hyperlipemia, current arrhythmia, hyperthyroidism, anemia and unstable blood pressure, which may undermine hemodynamic stability, or inability to cooperate sufficiently to complete the cerebral auto regulation examination * insufficient bilateral temporal bone windows for insonation of the middle cerebral artery * intolerance to cerebral autoregulation measurements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| phase difference(PD) in degree | 1 year | A dynamic cerebral auto-regulation parameter derived from transfer function analysis.Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler. Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Transfer function analysis will be used to derive the autoregulatory parameters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the rate of recovery of cerebral blood flow velocity | 1 year | A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as primary outcome |
| gain in cm/s/mmHg | 1 year | A dynamic cerebral auto-regulation parameter derived from transfer function analysis.The details are same as primary outcome |
| the consequence of electroencephalograph（EEG） | 1 year | — |
Countries
China
Outcome results
None listed