Dental Erosion
Conditions
Brief summary
Not only caries but also exposure to acids can lead to loss of tooth structure. This acid-related tooth structure loss is defined as dental erosion. A relationship between dental erosion and occurence of reflux disease was shown in numerous studies. On the one hand, patients with dental erosions frequently show reflux disease. On the other hand, many - but not all - reflux patients show dental erosions. It is believed that certain salivary parameters might explain, why not all reflux patients alike are affected of dental erosions. The aim of this study is to analyze the relationship and the extent of occurrence of dental erosions and reflux symptoms, including investigation of certain salivary parameters.
Interventions
Collection of saliva samples
OTHERVisual detection of BEWE-index
Visual detection of BEWE-index
Sponsors
University of Göttingen
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who are treated at the Clinic for Gastroenterology and Gastrointestinal Oncology and have a 24-hours pH monitoring or impedance measurement performed for medical reasons
Exclusion criteria
* Inability to give written consent * Age \<18 years * Intake of proton pump inhibitors (PPIs) if they are not discontinued at least one week before study participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual assessment of the BEWE-(basic erosive wear examination)-index | After removal of the probe (on second day) |
Secondary
| Measure | Time frame |
|---|---|
| Determination of unstimulated and stimulated saliva flow rate (ml/min). | While wearing the probe at three time points over 24h: morning, noon, evening |
| Determination of saliva pH and buffer capacity (mol/L). | While wearing the probe at three time points over 24h: morning, noon, evening |
| Determination of total protein content in saliva (g/L). | While wearing the probe at three time points over 24h: morning, noon, evening |
| Determination inorganic calcium and phosphate in saliva (mmol/L). | While wearing the probe at three time points over 24h: morning, noon, evening |
| Measurement of salivary enzyme activity: Protease, Kollagenase/Gelatinase, Pepsin, Trypsin, and Amylase (U/mL). | While wearing the probe at three time points over 24h: morning, noon, evening |
Outcome results
None listed