Myocardial Infarction, Percutaneous Coronary Intervention, PRCP
Conditions
Brief summary
Purpose: The purpose of this study is to evaluate the impact of acute ST-segment elevation myocardial infarction (STEMI) and primary percutaneous coronary intervention (PCI) on circulating prolylcarboxypeptidase (PRCP) level and activity.
Interventions
PROCEDUREPrimary PCI
Sponsors
Qilu Hospital of Shandong University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes; * Age ≥18 years; * Informed consent from subject or next of kin.
Exclusion criteria
* Nonischaemic Cardiomyopathy; * Cardiac surgery planed in the 6 months; * Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation); * Renal or hepatic failure; * Malignancy, HIV, or central nervous system disorder; * Cardiopulmonary resuscitation \>15 min and compromised level of consciousness; * Cardiogenic shock; * Current participation in any research study involving investigational drugs or devices; * No written consensus; * Previous myocardial infarction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circulating PRCP level | 1 month |
| Circulating PRCP activity | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Circulating Ang II level | 1 month |
| Circulating Ang-(1-7) level | 1 month |
| Circulating BK-(1-9) level | 1 month |
| Circulating KBK-(1-9) level | 1 month |
Countries
China
Outcome results
None listed