Preterm Infants, Respiratory Distress Syndrome In Premature Infants
Conditions
Brief summary
This study is to investigate the effect of a wide range of assistance levels on respiratory pattern, breathing variability including tidal volume and peak inspiratory pressure during neurally adjusted ventilatory assist (NAVA) in preterm infants. The investigators also aim to explore whether the effects of NAVA on the electrical activity of diaphragm (Edi) signal amplitude, work of breathing and comfort of preterm infants.
Interventions
DEVICEIncreasing and decreasing NAVA levels with 10-min intervals
Sponsors
Inha University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* preterm infants born before 36 weeks of gestational age * who received mechanical ventilatory care through the endotracheal tube at least 24 hours for respiratory distress * no use of anesthetics or analgetics
Exclusion criteria
* with major congenital anomalies (facial, gastrointestinal tract, cardiac, etc) * with phrenic nerve palsy or injuries
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| maximum Edi | the middle 2 minutes duration out of the total interval of 10 minutes | mean of recorded maximum electrical activities in the middle 2 min duration out of the total 10 min period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| comfort score | the 5-min point in the total 10-min period | calculated score of premature infant pain profile (PIPP) from the recorded video, heart rates and oxygen saturation |
| peak inspiratory pressure | the middle 2 minutes duration out of the total interval of 10 minutes | mean of recorded peak inspiratory pressures in the middle 2 min duration out of the total 10 min period |
| tidal volume | the middle 2 minutes duration out of the total interval of 10 minutes | mean of recorded expiratory tidal volumes in the middle 2 min duration out of the total 10 min period |
| inspiratory time in excess | the middle 2 minutes duration out of the total interval of 10 minutes | mean of calculated excessive inspiratory times from the calculation ((ventilator pressurization time-neural inspiratory time)/neural inspiratory time) from the middle 2 min duration out of the total 10 min period |
| electrical time product | the middle 2 minutes duration out of the total interval of 10 minutes | mean of calculated electrical time product from the middle 2 min duration out of the total 10 min period |
Countries
South Korea
Outcome results
None listed