Glioblastoma, Glioblastoma Multiforme
Conditions
Brief summary
The primary aim of this project is to Compare new msCS and standard DSC-PWI methods in GBM patients undergoing post-operative MRI for monitoring of tumor progression.
Detailed description
Investigators will compare the novel to the standard DSC-PWI methods in twenty five GBM patients to determine whether novel method improves image quality in tumor regions. We will also compare accuracy of pseudoprogression (PsP) vs. early progressive disease (ePD) determinations by the two techniques. If successful, the project will culminate in a novel imaging method sequence optimized to monitor progression and guide treatment decisions in post-operative GBM patients.
Interventions
PROCEDUREMRI
Sponsors
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
University of Wisconsin, Madison
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 82 Years
Healthy volunteers
No
Inclusion criteria
* Histology: Glioblastoma (grade 4 astrocytoma) * Standard-of-care, post-gd T1w image changes suggestive or consistent with of progression. * Standard-of-care MRI included conventional DSC-PWI without unexpected technical difficulties. * Methylation status of tumor available in medical record. * Able to provide written informed consent.
Exclusion criteria
* Contraindications either to 3T MRI (e.g. certain metallic and electronic implants, claustrophobia) or IV gadolinium contrast (allergy, pregnancy, breast-feeding, renal insufficiency). Screening for these contraindications will be based on history only (as it is for all routine outpatient clinical MRI at UWHC). * Significant physical or mental disease which would preclude successful compliance and participation in the study or, in the opinion of the principal investigator, or co-investigator, constitute a hazard, such that enrollment in the study would not be in the patient's best interest. * Special subjects such as minors, mentally disabled persons, or prisoners.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| A novel high resolution DSC-PWI imaging method | 2 years | A novel high resolution DSC-PWI method will be compared to the standard DSC-PWI method to determine whether novel method improves image quality in tumor regions. |
Countries
United States
Outcome results
None listed