Cognition Disorders, Sleep Apnea Syndromes, Obstructive
Conditions
Brief summary
The study assesses cognitive complaints in newly diagnosed patients with obstructive sleep apnea with no medical-comorbity affecting cognition. Cognitive complaints will be compared to healthy controls matched on age, sex and educational level. Factors related to cognitive complaints will also be assessed, including anxiety and depressive symptoms, complaints of fatigue and sleepiness, quality of life, psychological coping strategies and objective measures of cognition. Patients starting treatment for sleep apnea (continuous positive airway pressure or mandibular repositioning device) will be reassessed on all measures after 6 months of treatment to study the impact of treatment as usual on cognitive complaints and its related factors.
Interventions
BEHAVIORALquestionnaires and neuropsychological assessments
Sponsors
Tilburg University
Reinier de Graaf Groep
VieCuri Medical Centre
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* native Dutch speaker * estimated verbal-IQ of ≥80
Exclusion criteria
* other sleep disorder than obstructive sleep apnea * substance or alcohol abuse (e.g. no more than three units of alcohol per day for males and no more than two units of alcohol per day for females * diagnosis of a psychiatric disorder * use of medication effecting cognition * neurological disease, diabetes mellitus, hypo- or hyperthyroidism or lung disease (as checked by verbal report and medical records)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive Failure Questionnaire (CFQ) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | Questionnaire assessing cognitive complaints |
| Behavior Rating Inventory of Executive Function Adult version (BRIEF-A) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | Questionnaire assessing cognitive complaints |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fatigue Assessment Scale (FAS) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | questionnaire assessing fatigue |
| Epworth Sleepiness Scale (ESS) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | questionnaire assessing sleepiness |
| Pittsburgh Sleep Quality Index (PSQI) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | questionnaire screening for sleep disorders and assessing sleep quality |
| World Health Organisation Quality of Life Questionnaire BREF (WHOQOL-bref) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | questionnaire measuring quality of life |
| Utrechtse Coping Lijst (UCL) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | questionnaire measuring psychological coping strategies |
| Dutch reading tests for adults (NLV) | Assessed at inclusion of study. | cognitive test for verbal intelligence |
| Central Nervous System Vital Signs Symbol Digit Coding (CNS-VS-SDC) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for attention |
| Sleep diary | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | subjective measure for sleep quality |
| Central Nervous System Vital Signs Stroop Test (CNS-VS-ST) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for attention/executive function |
| Central Nervous System Vital Signs Shifting Attention Test (CNS-VS-SAT) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for attention/executive function |
| Rey Auditory Verbal Learning Test (RAVLT) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for memory |
| Wechsler Adult Intelligence Scale III - Digit Span (WAIS-III-DS) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for attention/executive function |
| Trail Making Test (TMT) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for attention/executive function |
| Semantic Fluency | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for executive function |
| Central Nervous System Vital Signs Continuous Performance Test (CNS-VS-CPT) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | cognitive test for attention |
| Hospital Anxiety and Depression Scale (HADS) | Assessed at inclusion of study and, if treatment is started, after 6 months of treatment. | questionnaire assessing anxiety and depressive symptoms |
Countries
Netherlands
Outcome results
None listed