Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients

Effects of Preanesthetic Dexmedetomidine on Hemodynamic Responses to Endotracheal Intubation in Elderly Patients Being Treated for Hypertension: A Randomized Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02768610

Enrollment

Registered

2016-05-11

Start date

2016-03-31

Completion date

2016-05-31

Last updated

2016-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Care

Keywords

dexmedetomidine

Brief summary

Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative 0.5 μg/kg dexmedetomidine on hemodynamic responses caused by endotracheal intubation in elderly patients being treated for hypertension. Methods: Forty elderly (≥ 65 years) treated-hypertensive patients of American Society of Anesthesiologists physical status II undergoing elective noncardiac surgery were randomly and assigned to two groups. Group C received normal saline and group D received 0.5 μg/kg dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were recorded preoperatively at ward, immediately after study drug administration, and at 1, 3, and 5 minutes after endotracheal intubation.

Interventions

DRUGDexmedetomidine

DRUGNormal Saline

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

65 Years to 85 Years

Healthy volunteers

Inclusion criteria

* American Society of Anesthesiologists physical status II * Scheduled for elective noncardiac surgery * Being treated with anti-hypertensive medication

Exclusion criteria

* Endotracheal intubation attempted more than twice * Morbidly obese (BMI \> 35 kg/m2)

Design outcomes

Primary

Measure	Time frame	Description
Changes in systolic blood pressure	2 minutes before intubation and 1, 3, 5 minutes after intubation	Units of Measure : mmHg
Changes in diastolic blood pressure	2 minutes before intubation and 1, 3, 5 minutes after intubation	Units of Measure : mmHg
Changes in mean arterial pressure	2 minutes before intubation and 1, 3, 5 minutes after intubation	Units of Measure : mmHg
Changes in heart rate	2 minutes before intubation and 1, 3, 5 minutes after intubation	Units of Measure : beats/min

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026