Optic Disc, Macula, and Retinal Nerve Fiber Layer Measurements Obtained by OCT in Thyroid Associated Ophthalmopathy

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02766660

Enrollment

102

Registered

2016-05-10

Start date

2012-01-31

Completion date

2013-01-31

Last updated

2016-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thyroid Associated Ophthalmopathy

Keywords

Thyroid ophthalmopathy, optical coherence tomography

Brief summary

The aim of the study is to compare the measurements of retinal nerve fiber layer (RNFL), macula and optical disc parameters obtained by optical coherence tomography (OCT), and intraocular pressure (IOP) between the patients with thyroid-associated ophthalmopathy (TAO) and healthy controls.

Detailed description

One hundred and thirty two eyes of 66 patients with TAO and 72 eyes of 36 healthy controls were included in the study. Proptosis level was determined by Hertel exophthalmometer. Optic disc, peripapillary retinal nerve fiber layer and macula parameters were measured by OCT. All measurements were compared between the patients and age and sex-matched healthy controls.

Interventions

DEVICEOptical Coherence Tomography

All groups were measured by optical coherence tomography.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

12 Years to 73 Years

Healthy volunteers

Yes

Inclusion criteria

Patient group consists the consecutive patients with thyroid associated ophthalmopathy consulted by endocrinology department. The control group was chosen among healthy volunteers who have * no eye pathology, * 20/20 vision (corrected or uncorrected), * age and sex-matched with the patient group.

Exclusion criteria

For both groups, those who had * significant sight impairment, * high myopia ( \< -5Diopters ), * high hyperopia ( \> +3Diopters ), * optic disc anomaly, * vitreoretinal interface disease, * vascular and degenerative retinal diseases, * cornea or lens opacity, ocular surgery history, * glaucoma, * neurological diseases that can affect the visual field, * history of trauma, amblyopia, * diplopia, * keratitis, * history of topical or systemic steroid

Design outcomes

Primary

Measure	Time frame	Description
Macular thickness	one year (between Jan 2012 and Jan 2013)	Macular thickness (micrometer) was measured by optical coherence tomography in patients and controls.
Retinal nerve fiber layer thickness	one year (between Jan 2012 and Jan 2013)	Retinal nerve fiber layer thickness (micrometer) was measured by optical coherence tomography in patient and control groups.

Secondary

Measure	Time frame	Description
Optic disc parameters	one year (between Jan 2012 and Jan 2013)	Optic disc parameters (morphologic structures) were obtained by optical coherence tomography for both groups.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026