Burns
Conditions
Brief summary
Three patients were recruited for assessment of ICG fluorescence in burns.
Detailed description
The early determination of healing potential in indeterminate thickness burns may be difficult to establish by visual inspection alone, even for experienced burn practitioners. This case series explores the use of indocyanine green (ICG) fluorescence using portable bedside assessment as a potential tool for early determination of burn depth. Three subjects with indeterminate thickness burns had daily perfusion assessment using ICG fluorescence assessment using the SPY machine (SPY®, Lifecell Corp., NJ, USA) in addition to standard burn care. The fluorescence was quantified as a percentage of the perfusion of intact skin, and areas of hypo and hyper-perfusion were indicated. The burn surgeon, blinded to the ICG results, made a clinical determination of the need for skin grafting or discharge. The perfusion in areas of differing depth of burn were compared over the entire study period to determine both the magnitude of difference, and the point in the time course of healing when these changes became evident.
Interventions
DEVICEICG/SPY
indocyanine green fluorescence imaging
Antibiotic ointment
Sponsors
Texas Tech University Health Sciences Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* patients with burn less than 15% TBSA
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perfusion of Burned Area | 5 days | Perfusion as measured by ICG Fluorescence |
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| ICG/SPY Daily wound care with antibiotic ointments after cleansing plus evaluation using ICG/SPY fluorescence.
ICG/SPY: indocyanine green fluorescence imaging
Antibiotic Ointment: Antibiotic ointment | 3 |
| Total | 3 |
Baseline characteristics
| Characteristic | ICG/SPY |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 1 Participants |
| Age, Categorical Between 18 and 65 years | 2 Participants |
| Sex: Female, Male Female | 2 Participants |
| Sex: Female, Male Male | 1 Participants |
| Size of burn | 7 % of body surface area |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 3 |
| serious Total, serious adverse events | 0 / 3 |
Outcome results
Primary
Perfusion of Burned Area
Perfusion as measured by ICG Fluorescence
Time frame: 5 days
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Patient 1 Superficial | Perfusion of Burned Area | Day 3 | 250 % perfusion compared to normal skin |
| Patient 1 Superficial | Perfusion of Burned Area | Day 2 | 300 % perfusion compared to normal skin |
| Patient 1 Superficial | Perfusion of Burned Area | Day 1 | 200 % perfusion compared to normal skin |
| Patient 1 Superficial | Perfusion of Burned Area | Day 5 | 205 % perfusion compared to normal skin |
| Patient 1 Superficial | Perfusion of Burned Area | Day 4 | 180 % perfusion compared to normal skin |
| Patient 1 Deep Tissue | Perfusion of Burned Area | Day 3 | 180 % perfusion compared to normal skin |
| Patient 1 Deep Tissue | Perfusion of Burned Area | Day 1 | 100 % perfusion compared to normal skin |
| Patient 1 Deep Tissue | Perfusion of Burned Area | Day 2 | 200 % perfusion compared to normal skin |
| Patient 1 Deep Tissue | Perfusion of Burned Area | Day 4 | 100 % perfusion compared to normal skin |
| Patient 1 Deep Tissue | Perfusion of Burned Area | Day 5 | 140 % perfusion compared to normal skin |
| Patient 2 Superficial | Perfusion of Burned Area | Day 1 | 205 % perfusion compared to normal skin |
| Patient 2 Superficial | Perfusion of Burned Area | Day 4 | 470 % perfusion compared to normal skin |
| Patient 2 Superficial | Perfusion of Burned Area | Day 5 | NA % perfusion compared to normal skin |
| Patient 2 Superficial | Perfusion of Burned Area | Day 3 | 280 % perfusion compared to normal skin |
| Patient 2 Superficial | Perfusion of Burned Area | Day 2 | 210 % perfusion compared to normal skin |
| Patient 2 Deep Tissue | Perfusion of Burned Area | Day 2 | 110 % perfusion compared to normal skin |
| Patient 2 Deep Tissue | Perfusion of Burned Area | Day 3 | 200 % perfusion compared to normal skin |
| Patient 2 Deep Tissue | Perfusion of Burned Area | Day 4 | 250 % perfusion compared to normal skin |
| Patient 2 Deep Tissue | Perfusion of Burned Area | Day 1 | 180 % perfusion compared to normal skin |
| Patient 2 Deep Tissue | Perfusion of Burned Area | Day 5 | NA % perfusion compared to normal skin |
| Patient 3 Superficial | Perfusion of Burned Area | Day 4 | 200 % perfusion compared to normal skin |
| Patient 3 Superficial | Perfusion of Burned Area | Day 2 | 180 % perfusion compared to normal skin |
| Patient 3 Superficial | Perfusion of Burned Area | Day 1 | 205 % perfusion compared to normal skin |
| Patient 3 Superficial | Perfusion of Burned Area | Day 3 | 500 % perfusion compared to normal skin |
| Patient 3 Superficial | Perfusion of Burned Area | Day 5 | NA % perfusion compared to normal skin |
| Patient 3 Deep Tissue | Perfusion of Burned Area | Day 3 | 380 % perfusion compared to normal skin |
| Patient 3 Deep Tissue | Perfusion of Burned Area | Day 4 | 150 % perfusion compared to normal skin |
| Patient 3 Deep Tissue | Perfusion of Burned Area | Day 2 | 190 % perfusion compared to normal skin |
| Patient 3 Deep Tissue | Perfusion of Burned Area | Day 1 | 110 % perfusion compared to normal skin |
| Patient 3 Deep Tissue | Perfusion of Burned Area | Day 5 | NA % perfusion compared to normal skin |