Postoperative Complications
Conditions
Keywords
Postoperative cognitive dysfunction, metabolic syndrome, propofol, sevoflurane
Brief summary
The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.
Detailed description
By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.
Interventions
OTHERmetabolic syndrome
metabolic syndrome
Sponsors
General Hospital of Ningxia Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* aged ≥60 years; * ASAⅡor Ⅲ * noncardiac surgery and nonneural surgery
Exclusion criteria
* Mini Mental State Examination \[MMSE\] score too low * chronic alcoho and drug abuse * disturbed renal and liver function * history of a cerebrovascular accident * permanent ventricular pacing * preoperative cognitive deficits * lack of cooperation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group | up to 7days postoperatively |
Outcome results
None listed