Chronic Kidney Diseases
Conditions
Keywords
Proteinuria, Propolis, Chronic Kidney Disease
Brief summary
The aim of this study is to determine the impact of Propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.
Interventions
DRUGPropolis
Patients will receive 500 mg / day of the propolis extract in the form of tablets split in two daily doses
DRUGPlacebo
Patients will receive 500 mg / day of the placebo in the form of tablets split in two daily doses
Sponsors
University of Sao Paulo General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* older than 18 years; * less than 90 years; * glomerular filtration rate between 25 and 70 ml / min; * proteinuria in the urine 24 hours more than 300 mg or protein / creatinina in isolated urine greater than 0.3g / g or microalbuminuria (albumin / creatinine ratio) between 30-300 mg / g.
Exclusion criteria
* Pregnants; * Neoplasia carrier; * Renal transplant patients; * Patients who refuse to participate in the study. * Glomerulopathy on Immunosuppression
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reducing Proteinuria | One year | Reduction from baseline proteinuria. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Protection of the glomerular filtration rate | One year | Maintaining glomerular filtration rate or inferior reduction to 5 ml per minute per 1.73 m2 of body-surface area from baseline. |
Countries
Brazil
Outcome results
None listed