Bipolar Disorder, Schizophrenia
Conditions
Brief summary
The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering simple visual stimuli and/or personal events.
Interventions
OTHERfMRI
Connectivity between the areas related to information processing over time and the areas activated during the rest activity. We will verify whether the activation anomalies observed during time tasks predict anomalies in spontaneous activity dynamics.
OTHEREEG
link between EEG response anomalies related to information processing over time and response anomalies recorded during rest activity. We will check whether anomalies in EEG oscillatory responses during time tasks predict anomalies during the rest task.
Sponsors
Fondation pour la Recherche Médicale (FRM)
University Hospital, Strasbourg, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18 and 60 years * Affiliation to a social security insurance * Written consent given * Only for patient : DSM criteria for schizophrenia or bipolar disorder
Exclusion criteria
* Addiction problem * Invalidating visual sensory problems * Neurological history * Pregnancy or breastfeeding * Legal safeguard * Participation in another clinical trial * Contraindication to MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abnormalities in connectivity during order judgement tasks will be taken as seeds to check whether they account for abnormalities in connectivity at rest, by means of mathematic modelization | After study completion (2 years) |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during rest. | After study completion (2 years) |
| - Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during time ordering. | After study completion (2 years) |
| Comparison of patients with schizophrenia vs. bipolar disorder | During fMRI and EEG sessions |
Countries
France
Outcome results
None listed