Coronary Artery Disease (CAD)
Conditions
Keywords
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Brief summary
Coronary revascularization improves survival for patients with coronary artery disease. However,many patients are left with poor physical and mental health. Traditional cardiac rehabilitation involves moderate intensity continuous exercise (MICE). Alternatives to traditional cardiac rehabilitation programming may however provide superior understudied benefits to patients with poor physical and mental health. Nordic walking (NW) and high-intensity interval training (HIIT) are two examples of alternative programs for cardiac rehabilitation, which may provide superior physical and mental health benefits when compared to traditional MICE. The main purpose of this project is, therefore, to determine the short and long term physical and mental health benefits of alternative cardiac rehabilitation modalities, including NW and HIIT on exercise capacity, quality of life and depression after a 12-week program.
Interventions
BEHAVIORALHigh Intensity Interval Training
Participants will complete supervised exercise sessions. Participants will attend on-site high-intensity interval training two times weekly for 12 weeks
Participants will complete supervised exercise sessions. Moderate-intensity continuous exercise training will follow cardiovascular rehabilitation guidelines. Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks.
BEHAVIORALNordic Walking
Participants will complete supervised exercise sessions. Participants will attend on-site Nordic walking training two times weekly for 12 weeks
Sponsors
Ontario Ministry of Health and Long Term Care
Heart and Stroke Foundation of Canada
Ottawa Heart Institute Research Corporation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patient with CAD who recently underwent PCI (within 2-10 weeks) PCI or coronary artery bypass grafting (within the last 18 weeks); * Patient is referred to University of Ottawa Heart Institute cardiac rehabilitation program; * Patient is able to walk independently * Patient is willing to attend an onsite cardiac rehabilitation program twice weekly for 12 weeks; * At least 40 years of age; * Patient is willing and able to provide informed consent
Exclusion criteria
* Currently participating in routine exercise training (\>2x/week) and/or using Nordic Walking poles; * Active infection or inflammatory condition; * Over 75 years of age; * Persistent or permanent atrial fibrillation; * Pregnant, lactating or planning to become pregnant during the trial period; * Unstable angina or established diagnosis of chronic obstructive pulmonary disease, severe mitral or aortic stenosis, or hypertrophic obstructive cardiomyopathy; * Unable to read and understand English or French; * Unwilling or unable to return for follow-up visit at weeks 12 and 26;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise Capacity | Baseline to 12 weeks and Baseline to 26 weeks | Changes in exercise capacity from baseline to 12 weeks and baseline to 26 weeks are measured by the six-minute walk test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Aortic stiffness | Baseline to 12 weeks and Baseline to 26 weeks | Changes in aortic stiffness from baseline to 12 weeks and baseline to 26 weeks are measured by pulse wave velocity |
| Body Composition | Baseline to 12 weeks and Baseline to 26 weeks | Changes in body composition from baseline to 12 weeks and baseline to 26 weeks are measured by the waist circumference. |
| Depression | Baseline to 12 weeks and Baseline to 26 weeks | Changes in depression from baseline to 12 weeks and baseline to 26 weeks are measured by the Beck Depression Inventory-II questionnaire |
| Quality of Life - SF36 | Baseline to 12 weeks and Baseline to 26 weeks | Changes in quality of life from baseline to 12 weeks and baseline to 26 weeks are measured by the Short Form-36. |
| Functional Fitness | Baseline to 12 weeks and Baseline to 26 weeks | Changes in functional fitness from baseline to 12 weeks and baseline to 26 weeks are measured by the Senior Fitness Test |
| Exercise Adherence | Baseline to 12 weeks and Baseline to 26 weeks | Changes in exercise adherence from baseline to 12 weeks and baseline to 26 weeks are measured by the Actigraph accelerometer |
| Depression mechanisms | Baseline to 12 weeks and Baseline to 26 weeks | Changes in depression mechanisms from baseline to 12 weeks and baseline to 26 weeks are measured by plasma brain derived neurotrophic factor. |
| Lipid and glucose profile | Baseline to 12 weeks and Baseline to 26 weeks | Changes in lipid and glucose profile from baseline to 12 weeks and baseline to 26 weeks are measured by plasma total cholesterol. |
| Quality of Life - HeartQoL | Baseline to 12 weeks and Baseline to 26 weeks | Changes in quality of life from baseline to 12 weeks and baseline to 26 weeks are measured by the HeartQoL questionnaire |
Countries
Canada
Outcome results
None listed