Aerosol Delivery in Different Types of Nebulizers

Evaluation of Aerosol Delivery in Different Types of Nebulizers

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02764307

Enrollment

Registered

2016-05-06

Start date

2015-10-31

Completion date

2016-12-31

Last updated

2017-02-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Brief summary

Background: Nebulizers design influences efficiency of aerosol delivery. Performance of nebulizers is commonly tested by breathing simulators with static parameters. However, breathing patterns vary in adults. Objectives: The purpose of this study was to evaluate drug deposition of different types of nebulizers testing with breathing patterns of healthy subjects.

Detailed description

Material and Methods The study was approved by Chang Gung Memorial Foundation Institutional Review Broad. Ten healthy subjects, aged 20.6±0.5 years, were recruited. Four nebulizers: 1. a constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan); 2. a breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany); 3. a manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan); and 4. a breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) were evaluated.

Interventions

DEVICEConstant jet nebulizer

A constant jet nebulizer (Neb-easy, Galemed Corp., Taiwan) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.

DEVICEBreath enhanced nebulizer

A breath enhanced nebulizer (Pari LC plus, Pari Inc., Germany) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.

DEVICEManual-actuated nebulizer

A manual-actuated nebulizer (A-T Neb, Atlantean Corporation, Taiwan) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.

DEVICEBreath-actuated nebulizer

A breath-actuated nebulizer (AeroElipes, Trudell Medical Inc, Canada) was tested with salbutamol sulfate powered by compressed gas flow at 6 L/min.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 25 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy college subjects

Exclusion criteria

* Currently smoker * History of asthma * Drug allergy * Pulmonary disease * Heart disease * Arrythmia * Hyperthyroids * Diabetes mellitus * Lactacidosis * Pregnant * Under B-blocker medications

Design outcomes

Primary

Measure	Time frame	Description
Inhaled and exhaled drug concentrations	Drug deposition was tested Immediately after each nebulization, expected average of 20 minutes	Drug deposited on the collecting filter was analyzed.

Secondary

Measure	Time frame	Description
Breathing parameters	During each nebulization testing, an expected average of 10 minutes	Minute ventilation was recorded during nebulization

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026