Insect Sting Allergy
Conditions
Keywords
insect sting allergy, recombinant venom allergen
Brief summary
Study the causative insect by skin prick test and sIgE to wasp, bee and fire ants are important but false positive by crossreactivity can occur. sIgE to recombinant venom allergen is proposed to help in finding the causative insect.
Detailed description
Insect sting allergy from insects in Hymenoptera is not uncommon. The reaction maybe very severe and life threatening. To find the cause of insect sting allergy is important in prevention and specific treatment such as immunotherapy. The skin prick test and sIgE of these insects may have cross reactions so it is difficult to be interpreted. The usage of sIgE recombinant venom allergen can benefit in separate cross reaction and dual allergy reaction.
Interventions
OTHERSkin prick test
Skin prick tests to local and imported insect sting allergen with different concentration are performed.
OTHERsIgE measurement
sIgE levels to stinging insect allergen and their recombinant venom allergen are measured
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Cases with severe insect sting allergy reactions
Exclusion criteria
* Without other severe systemic diseases * Not pregnant or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean wheal diameters of skin prick test of local and imported insect allergens | 12 months | Compare Mean wheal diameters of skin prick test of local and imported insect allergens at different concentrations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| specific IgE level to stinging insect allergen and recombinant venom allergens | 12 months | compare skin prick test result and levels of specific IgE level to stinging insect allergen and recombinant venom allergens |
Outcome results
None listed