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The Role of Different Imaging Methods in the Diagnosis of Gallbladder Polyps

The Role of Different Imaging Methods in the Diagnosis of Gallbladder Polyps

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02762227
Enrollment
500
Registered
2016-05-04
Start date
2016-08-31
Completion date
2020-12-31
Last updated
2020-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polyp of Gallbladder

Keywords

CEUS, CT, gallbladder cholesterol polyps, adenoma, gallbladder cancer

Brief summary

This prospective cohort study is designed to investigate and to compare the diagnostic performance of contrast-enhanced ultrasonography (CEUS) and multidetector computed tomography (CT) for gallbladder cholesterol polyps, adenoma and gallbladder cancer.

Detailed description

In this study, investigators aimed to investigate the diagnostic performance of CEUS and high resolution CT (HRCT) for the preoperative differential diagnostic accuracies of gallbladder polypoid lesions.

Interventions

DEVICEAbdominal high resolution CT

CT examinations were performed using a 64-slice CT scanner. Arterial phase scanning was triggered by bolus tracking technique after 100 to 120 mL nonionic contrast material was injected through the antecubital vein. With a delay of 60 and 140 s after the beginning of contrast medium injection, portal venous and equilibrium phase image scanning were followed.

DEVICEContrast-enhanced ultrasonography (CEUS)

CEUS examinations were performed using a Philips iU 22 scanner with a 1-5 MHz(Mega Hertz, MHz)vector transducer. Traditional transabdominal ultrasound and CEUS were performed by the same investigator, one with more than 3 years experiences in CEUS. Traditional ultrasound was used initially to locate the lesion. The plane with the bottom of the lesion was selected for further examination. When multiple lesions were existed, the largest one was selected to evaluate. The target was placed in the center of the screen and was kept stable. Pulse inversion harmonic imaging with an index of 0.06 was used in CEUS examination. SonoVue, which contained sulfur hexafluoride microbubbles, was used as the contrast agent.

PROCEDURECholecystectomy

Cholecystectomy is performed by method of either laparoscopic cholecystectomy or open cholecystectomy.

Sponsors

RenJi Hospital
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* All patients with a gallbladder polypoid lesion visited our department, diagnosed by conventional transabdominal US.

Exclusion criteria

* Gallbladder polyp with a diameter less than 10 mm. * Lesions highly suspected to be cancer due to visible metastasis. * Allergy to contrast agents and cannot received CT or CEUS examination. * Women in pregnancy or lactation.

Design outcomes

Primary

MeasureTime frame
Pathological diagnosis of gallbladder polyps (Cholesterol / Adenoma / Others)intraoperative

Countries

China

Contacts

Primary ContactTAO CHEN, M.D.
dr_chentao78@163.com+8613601779874
Backup ContactYUNHE ZHANG, M.D.
zyhe31@163.com+8613917908722

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026