Acute Coronary Syndrome, Myocardial Infarction, Percutaneous Coronary Intervention
Conditions
Keywords
antiplatelet, stent thrombosis
Brief summary
ONASSIST is a registry of coronary ill patients who have had a functional test measuring anti-platelet effect and/or a genetic profile of response to anti-platelet drugs.
Detailed description
The Onassist Project is an assistance for cardiologists that establishes an individual risk of stent thrombosis for each patient based on: * a functional approach (evaluation of the antiplatelet effect of the antiplatelet regimen by multiple tests) and * a pharmacogenomic approach (genetic profile of response to antiplatelet agents) It provides advices for specific therapeutics after identification of adverse drug interactions, treatment compliance issues and true genetic, functional or mixed resistance. This individualized strategy allow to adjust the choice of the drugs and their optimal dosage considering the best benefit - risk ratio. Follow up are regularly made to identify markers of MACE (major adverse cardiac event) or bleeding.
Interventions
None listed
Sponsors
Action, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* coronary disease * antiplatelets testing performed as part of usual care and / or gentic profile of antiplatelet response done
Exclusion criteria
* patient refusing to be part of the registry
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Myocardial Infarction | 10 years | — |
| Death | 10 years | — |
| Stroke | 10 years | — |
| Bleeding | 10 years | all bleeding according to the BARC (Bleeding Academic Research Consortium) definitions are registered during the follow up |
| Urgent Revascularization | 10 years | — |
| Resuscitated Cardiac Arrest | 10 years | — |
Countries
France
Contacts
Primary ContactJean Philippe COLLET, MD, PhD
Backup ContactDelphine Brugier, PhD
Outcome results
None listed