The Relationship Between White Matter Hyperintensity With Cognition and Emotion

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02761148

Enrollment

200

Registered

2016-05-04

Start date

2014-01-31

Completion date

2019-12-31

Last updated

2017-06-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aged, Leukoaraiosis

Keywords

white matter hyperintensity, brain network, MRI, cognition, emotion

Brief summary

White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

1. white matter hyperintensity visible on T2 fluid-attenuated inversion recovery images; 2. age between 35 to 80 years; 3. without stroke lesion (except lacunar infarction) on current diffusion weighted images; 4. without a history of multiple sclerosis, Alzheimer's disease, Parkinson's disease and head trauma.

Exclusion criteria

1. white matter lesions of nonvascular origin (immunological-demyelinating, metabolic, toxic, infectious, other); 2. intracranial hemorrhage; 3. with severe head motion on magnetic resonance images

Design outcomes

Primary

Measure	Time frame
Fazekas Scale of white matter hyperintensity	1 year
Mini-Mental State Examination (MMSE)	1 year
Hamilton Depression Scale (HAMD)	1 year

Countries

China

Contacts

Primary ContactMinming Zhang, Ph.D

zhangminming@zju.edu.cn13906520711

Outcome results