Locally Advanced Papillary Renal Cell Carcinoma, Metastatic Papillary Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v7, Stage IV Renal Cell Cancer AJCC v7, Type 1 Papillary Renal Cell Carcinoma, Type 2 Papillary Renal Cell Carcinoma, Unresectable Renal Cell Carcinoma
Conditions
Brief summary
This phase II trial studies how well cabozantinib s-malate, crizotinib, savolitinib, or sunitinib malate work in treating patients with kidney cancer that has spread from where it started to nearby tissue or lymph nodes or to other places in the body. Cabozantinib s-malate, crizotinib, savolitinib, and sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving cabozantinib s-malate, crizotinib, or savolitinib will work better in treating patients with kidney cancer compared to sunitinib malate.
Detailed description
PRIMARY OBJECTIVE: I. To compare progression-free survival (PFS) in patients with metastatic papillary renal cell carcinoma (mPRCC) treated with sunitinib malate (sunitinib) to PFS in patients with mPRCC treated with MET kinase inhibitors. SECONDARY OBJECTIVES: I. To compare Response Evaluation Criteria in Solid Tumors (RECIST) response rate (RR; defined as the combined rate of confirmed and unconfirmed partial response \[PR\] and confirmed and unconfirmed complete response \[CR\]) in patients with mPRCC treated with sunitinib to RR in patients treated with putative MET inhibitors. II. To compare overall survival (OS) in patients with mPRCC treated with sunitinib to OS in patients with mPRCC treated with putative MET inhibitors. III. To compare the safety profile of sunitinib and putative MET inhibitors in patients with mPRCC. TRANSLATIONAL OBJECTIVES: I. To evaluate the prognostic and predictive value of MET mutations, MET copy number or other markers of MET signaling in patients with mPRCC treated with putative MET inhibitors. II. To estimate the frequency of high oncometabolite levels in formalin-fixed, paraffin-embedded (FFPE) tissues of patients with advanced papillary renal cell carcinoma by liquid chromatography-mass spectrometry (LC-MS/MS) and estimate progression free survival for those with and without high oncometabolite levels being treated. III. To correlate the mutational signature suggestive of a homologous recombination defect with high oncometabolite levels in patients with papillary renal cell carcinoma pRCC. OUTLINE: Patients are randomized to 1 of 4 treatment arms. As of 12/5/18, patients will only be randomized to Arm I or Arm II. ARM I: Patients receive sunitinib malate orally (PO) once daily (QD) on days 1-28. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo computed tomography (CT) at screening and on study, undergo bone scan as clinically indicated, and undergo collection of plasma and serum samples at screening, on study, and during follow up. ARM II: Patients receive cabozantinib s-malate PO QD on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT at screening and on study, undergo bone scan as clinically indicated, and undergo collection of plasma and serum samples at screening, on study, and during follow up. ARM III (CLOSED TO ACCRUAL 12/5/18): Patients receive crizotinib PO twice daily (BID) on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT at screening and on study, undergo bone scan as clinically indicated, and undergo collection of plasma and serum samples at screening, on study, and during follow up. ARM IV (CLOSED TO ACCRUAL 12/5/18): Patients receive savolitinib PO QD on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity. Patients also undergo CT at screening and on study, undergo bone scan as clinically indicated, and undergo collection of plasma and serum samples at screening, on study, and during follow up. After completion of study treatment, patients are followed up for 3 years.
Interventions
PROCEDUREBiospecimen Collection
Undergo collection of plasma and serum samples
PROCEDUREBone Scan
Undergo bone scan
DRUGCabozantinib S-malate
Given PO
PROCEDUREComputed Tomography
Undergo CT
DRUGCrizotinib
Given PO
DRUGSavolitinib
Given PO
DRUGSunitinib Malate
Given PO
Sponsors
Canadian Cancer Trials Group
National Cancer Institute (NCI)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients must have histologically or cytologically confirmed papillary histology renal cell carcinoma which is metastatic or locally advanced disease not amenable to surgical resection; (NOTE: a designation of type I or type II should be made by the local pathologist if possible); mixed histologies containing type I or type II will be allowed provided that they contain \>= 50% of the papillary component * Patients must also have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension; disease X-rays, scans or physical examinations used for tumor measurement must have been completed within 28 days prior to registration; if there is clinical suspicion for bone metastases at the time of enrollment (at the discretion of the investigator), bone scan should be performed at baseline (within 42 days prior to registration); all disease must be assessed and documented on the Baseline Tumor Assessment form * Patients with a history of treated brain metastases who are asymptomatic and have not received steroid therapy in the 14 days prior to registration are eligible; anti-seizure medications are allowed provided they are non-enzyme inducing (e.g. topiramate, levetiracetam, gabapentin) * Patients must not have cavitating pulmonary lesions; patients must not have tumor invading the gastrointestinal (GI) tract or evidence of endotracheal or endobronchial tumor within 28 days prior to registration * Patients may have received prior surgery; at least 28 days must have elapsed since surgery and patient must have recovered from any adverse effects of surgery * Patients may have received up to one prior systemic therapy for advanced or metastatic renal cell carcinoma with the exception of another VEGF inhibitor Food and Drug Administration (FDA)-approved for advanced renal cell carcinoma (RCC) (i.e., pazopanib, bevacizumab, sorafenib or axitinib); if a patient develops metastatic disease within six months of discontinuation of adjuvant therapy, this will constitute one prior systemic therapy for advanced or metastatic RCC; if a patient develops metastatic disease and more than six months has elapsed since discontinuation of adjuvant therapy, this will not constitute prior systemic therapy for advanced or metastatic RCC; patients may have also received prior immunotherapy; patients must not have received a MET/hepatocyte growth factor (HGF) inhibitor or sunitinib as prior therapy; at least 14 days must have elapsed since completion of prior systemic therapy; patients must have recovered from all associated toxicities at the time of registration * Patients may have received prior radiation therapy, but must have measurable disease outside the radiation port; at least 14 days must have elapsed since completion of prior radiation therapy; patients must have recovered from all associated toxicities at the time of registration * Patients must not be taking, nor plan to take while on protocol treatment, strong CYP3A4 inhibitors (e.g. boceprevir, cobicistat, danoprevir, elvitegravir/RIT, fluvoxamine, indinavir, itraconazole, ketoconazole, lopinavir/RIT, nefazodone, nelfinavir, posaconazole, ritonavir, telaprevir, telithromycin, tipravavir/RIT, or voriconazole); strong CYP3A4 inducers (e.g. avasimibe, phenytoin, rifampin, rifabutin); potent inhibitors of CYP1A2 (e.g. ciprofloxacin); and/or drugs known to be CYP3A4 substrates with a narrow therapeutic range (e.g., diergotamine, ergotamine) within 14 days prior to randomization; moderate inhibitors or inducers of isoenzyme CYP3A4 should be avoided, but if necessary can be used with caution * Patients must not be receiving or planning to receive any other investigational agents * Patients must have a complete physical examination and medical history within 28 days prior to registration * Patients must have a Zubrod performance status of 0 - 1 * White blood cell count (WBC) \>= 2,000/mcL (must be obtained within 28 days prior to registration) * Absolute neutrophil count (ANC) \>= 1,000/mcL (must be obtained within 28 days prior to registration) * Platelet count \>= 75,000/mcL (must be obtained within 28 days prior to registration) * Serum bilirubin =\< 1.5 x institutional upper limits of normal (ULN) (must be obtained within 28 days prior to registration) * Serum transaminase (serum glutamic oxaloacetic transaminase \[SGOT\]/aspartate aminotransferase \[AST\] and serum glutamate pyruvate transaminase \[SGPT\]/alanine aminotransferase \[ALT\]) must be =\< 2.5 x the institutional ULN unless the liver is involved with the tumor, in which case serum transaminase (SGOT/SGPT) must be =\< 5 x the institutional ULN (must be obtained within 28 days prior to registration) * Serum creatinine must be =\< 2 x the institutional ULN OR creatinine clearance (either measured or calculated) must be \> 30 mL/min (must be obtained within 28 days prior to registration) * Patients must not have any clinical evidence of congestive heart failure (CHF) (specifically, New York Heart Association \[NYHA\] class III \[moderate\] or class IV \[severe\]) at the time of registration; baseline echocardiogram within 28 days of registration must demonstrate an ejection fraction (EF) \>= 50%; due to the potential cardiac toxicity of the agents utilized in this protocol, patients must have corrected QT (QTc) interval \< 500 msec on prestudy electrocardiogram (EKG) and no known history of congenital long QT syndrome; patients must not have experienced unstable angina pectoris, clinically significant cardiac arrhythmias, or stroke (transient ischemic attack \[TIA\] or other ischemic event) within 3 months prior to registration and not have experienced myocardial infarction or thromboembolic event requiring anticoagulation within 6 months of registration; prestudy EKG must be obtained within 28 days prior to registration * Baseline urinalysis should show urine protein \< 3+ and must be obtained within 28 days prior to registration; if urine protein is 3+ or greater, then urine protein by 24 hour collection must show less than 3 grams of protein * Patients must not have inadequately controlled hypertension; patients must have documented blood pressures of systolic blood pressure (SBP) \< 150 and diastolic blood pressure (DBP) \< 90 within 14 days of starting randomization; blood pressure medications (any number) are permitted * Patients must be able to take oral medications (i.e., swallow pills whole); patients must not have gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for intravenous (IV) alimentation, prior surgical procedures that could in the opinion of the treating investigator affect absorption, or active peptic ulcer disease; patients with intractable nausea or vomiting are not eligible * Patients must not have had any clinically-significant GI bleeding within 6 months prior to registration and patients must not have a GI disorder which (at the discretion of the investigator) bears a high risk of perforation or fistula; examples of this include (but are not limited to) Crohn's disease or tumor with transmural extension through the gastrointestinal lining * Patients must not have had hemoptysis of \>= 0.5 teaspoon (2.5 ml) of red blood within 3 months prior registration * Patients must not demonstrate any other signs indicative of pulmonary hemorrhage within 3 months prior to registration * Patient's baseline imaging must not indicate the presence of tumor invading or encasing any major blood vessels * Patients must not have any unresolved wounds from previous surgery * Albumin, alkaline phosphatase, bicarbonate, blood urea (BUN), chloride, glucose, phosphorus, and total protein must be assessed within 28 days of registration * No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for 3 years; men receiving active surveillance for prostate cancer may also be enrolled * Due to the unknown effects of the study drugs, patients must not be pregnant or nursing; women/men of reproductive potential must have agreed to use an effective contraceptive method while receiving study drug and for three months after last dose of study drug; a woman is considered to be of reproductive potential if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, effective contraception also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures * Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with cabozantinib, crizotinib, savolitinib or sunitinib; in addition these patients are at increased risk of lethal infections when treated with marrow suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated * Patients must be \>= 18 years of age * Patients must have tissue available and be willing to submit for independent pathologic review in order to classify type I versus type II papillary disease * Patients must be offered the opportunity to participate in specimen banking for future translational medicine studies * Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines * As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression Free Survival (PFS) | From date of registration to date of first documentation of progression or symptomatic deterioration, or death due to any cause; assessed up to 3 years | Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), as a 20% increase in the sum of appropriate diameters of target lesions over smallest sum observed, or a measurable increase in a non-target lesion, or the appearance of new lesions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Response Rate (RR) | Up to 3 years | The response rate (RR) is defined as the combined rate of confirmed and unconfirmed partial response and confirmed and unconfirmed complete response. Complete response (CR) is defined as the complete disappearance of all target and non-target lesions, along with no new lesions. Partial response (PR) is defined as \>=30% decrease of the sum of appropriate diameters of all target measurable lesions, along with no new lesions. |
| Overall Survival (OS) | Up to 3 years | Duration from date of randomization to date of death from any cause. |
| Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Duration of treatment and follow up until death or 3 years post registration | Only adverse events that are possibly, probably or definitely related to study drug are reported. |
Other
| Measure | Time frame | Description |
|---|---|---|
| MET Mutation Rate | Up to 3 years | The hazard ratio between the MET inhibitor versus (vs.) sunitinib in those with versus without the mutation (i.e., the interaction) will be compared. Response Evaluation Criteria in Solid Tumors (RECIST) response rate (confirmed and unconfirmed partial response and complete response) based on MET mutation/expression level will be compared using the chi-square test. |
Countries
Canada, United States
Participant flow
Recruitment details
152 participants were enrolled and randomly assigned. Five participants were excluded because of inadequate baseline disease assessment or no evidence of metastatic disease. Therefore, 147 were deemed eligible and analyzable for the primary analysis.
Participants by arm
| Arm | Count |
|---|---|
| Arm I (Sunitinib Malate) Patients receive sunitinib malate PO on days 1-28. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.
Sunitinib Malate: Given PO | 46 |
| Arm II (Cabozantinib S-malate) Patients receive cabozantinib s-malate PO on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.
Cabozantinib S-malate: Given PO | 44 |
| Arm III (Crizotinib Closed to Accrual 12/5/18) Patients receive crizotinib PO BID on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.
Crizotinib: Given PO | 28 |
| Arm IV (Savolitinib Closed to Accrual 12/5/18) Patients receive savolitinib PO on days 1-42. Cycles repeat every 42 days in the absence of disease progression or unacceptable toxicity.
Savolitinib: Given PO | 29 |
| Total | 147 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 | FG002 | FG003 |
|---|---|---|---|---|---|
| Overall Study | Adverse Event | 11 | 9 | 5 | 3 |
| Overall Study | Currently On Study Treatment | 0 | 3 | 0 | 0 |
| Overall Study | Death | 2 | 2 | 1 | 1 |
| Overall Study | Ineligible - Inadequate Baseline Disease Assessment | 1 | 1 | 0 | 0 |
| Overall Study | Ineligible - No Measurable Disease | 1 | 1 | 0 | 1 |
| Overall Study | Other - Not Protocol Specified | 2 | 1 | 2 | 0 |
| Overall Study | Progression/Relapse | 29 | 27 | 20 | 23 |
| Overall Study | Refusal Unrelated to Adverse Event | 2 | 2 | 0 | 2 |
Baseline characteristics
| Characteristic | Total | Arm I (Sunitinib Malate) | Arm II (Cabozantinib S-malate) | Arm III (Crizotinib Closed to Accrual 12/5/18) | Arm IV (Savolitinib Closed to Accrual 12/5/18) |
|---|---|---|---|---|---|
| Age, Continuous | 66 years | 65 years | 65 years | 68 years | 67 years |
| Ethnicity (NIH/OMB) Hispanic or Latino | 5 Participants | 0 Participants | 2 Participants | 1 Participants | 2 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 136 Participants | 46 Participants | 40 Participants | 26 Participants | 24 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 6 Participants | 0 Participants | 2 Participants | 1 Participants | 3 Participants |
| Histological Subtype (Central Assessment) Missing | 8 Participants | 2 Participants | 2 Participants | 1 Participants | 3 Participants |
| Histological Subtype (Central Assessment) Mixed or Other | 35 Participants | 11 Participants | 12 Participants | 5 Participants | 7 Participants |
| Histological Subtype (Central Assessment) Type 1 | 41 Participants | 12 Participants | 14 Participants | 9 Participants | 6 Participants |
| Histological Subtype (Central Assessment) Type 2 | 63 Participants | 21 Participants | 16 Participants | 13 Participants | 13 Participants |
| Histological Subtype (Local Assessment) Not otherwise specified | 41 Participants | 14 Participants | 10 Participants | 8 Participants | 9 Participants |
| Histological Subtype (Local Assessment) Type 1 | 27 Participants | 8 Participants | 9 Participants | 5 Participants | 5 Participants |
| Histological Subtype (Local Assessment) Type 2 | 79 Participants | 24 Participants | 25 Participants | 15 Participants | 15 Participants |
| IMDC Risk Group Favourable | 38 Participants | 14 Participants | 10 Participants | 8 Participants | 6 Participants |
| IMDC Risk Group High | 20 Participants | 6 Participants | 6 Participants | 4 Participants | 4 Participants |
| IMDC Risk Group Intermediate | 89 Participants | 26 Participants | 28 Participants | 16 Participants | 19 Participants |
| Metastatic Sites of Interest Bone | 26 Participants | 7 Participants | 6 Participants | 5 Participants | 8 Participants |
| Metastatic Sites of Interest CNS | 1 Participants | 0 Participants | 0 Participants | 1 Participants | 0 Participants |
| Previous Nephrectomy | 113 Participants | 34 Participants | 32 Participants | 26 Participants | 21 Participants |
| Previous Systemic Therapy | 10 Participants | 3 Participants | 2 Participants | 2 Participants | 3 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 1 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants |
| Race (NIH/OMB) Asian | 3 Participants | 1 Participants | 1 Participants | 1 Participants | 0 Participants |
| Race (NIH/OMB) Black or African American | 21 Participants | 5 Participants | 9 Participants | 4 Participants | 3 Participants |
| Race (NIH/OMB) More than one race | 1 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 1 Participants | 1 Participants | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 6 Participants | 0 Participants | 2 Participants | 1 Participants | 3 Participants |
| Race (NIH/OMB) White | 114 Participants | 39 Participants | 32 Participants | 22 Participants | 21 Participants |
| Sex: Female, Male Female | 35 Participants | 11 Participants | 8 Participants | 6 Participants | 10 Participants |
| Sex: Female, Male Male | 112 Participants | 35 Participants | 36 Participants | 22 Participants | 19 Participants |
| Zubrod Performance Score 0 | 91 Participants | 29 Participants | 29 Participants | 18 Participants | 15 Participants |
| Zubrod Performance Score 1 | 56 Participants | 17 Participants | 15 Participants | 10 Participants | 14 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | 24 / 46 | 22 / 44 | 16 / 28 | 21 / 29 |
| other Total, other adverse events | 44 / 45 | 41 / 43 | 26 / 27 | 27 / 28 |
| serious Total, serious adverse events | 15 / 45 | 19 / 43 | 8 / 27 | 11 / 28 |
Outcome results
Primary
Progression Free Survival (PFS)
Progression is defined using Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1), as a 20% increase in the sum of appropriate diameters of target lesions over smallest sum observed, or a measurable increase in a non-target lesion, or the appearance of new lesions
Time frame: From date of registration to date of first documentation of progression or symptomatic deterioration, or death due to any cause; assessed up to 3 years
Population: Analysis population included eligible participants.
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Sunitinib | Progression Free Survival (PFS) | 5.6 months |
| Cabozantinib | Progression Free Survival (PFS) | 9.0 months |
| Crizotinib | Progression Free Survival (PFS) | 2.8 months |
| Savolitinib | Progression Free Survival (PFS) | 3.0 months |
Comparison: A proportional hazards model was used to compare the Hazard Ratio (HR) for PFS.p-value: 0.01995% CI: [0.37, 0.97]Regression, Cox
Secondary
Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs
Only adverse events that are possibly, probably or definitely related to study drug are reported.
Time frame: Duration of treatment and follow up until death or 3 years post registration
Population: Eligible participants who received at least one dose of protocol treatment.
| Arm | Measure | Group | Value (NUMBER) |
|---|---|---|---|
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoxia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypophosphatemia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fatigue | 3 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | White blood cell decreased | 5 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyponatremia | 2 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypomagnesemia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Febrile neutropenia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus tachycardia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypocalcemia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoalbuminemia | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Gastrointestinal disorders - Other, specify | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus bradycardia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypertension | 9 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypermagnesemia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Generalized muscle weakness | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anorexia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyperkalemia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypercalcemia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Genital edema | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vascular disorders - Other, specify | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hematoma | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hearing impaired | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Reproductive system and breast disorders - Other | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Renal calculi | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Aspartate aminotransferase increased | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thrombotic thrombocytopenic purpura | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Rash maculo-papular | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Proteinuria | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Back pain | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Alanine aminotransferase increased | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pneumonitis | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pleural effusion | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Confusion | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Abdominal pain | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Platelet count decreased | 2 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Paronychia | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dehydration | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vomiting | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pancreatitis | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Palmar-plantar erythrodysesthesia syndrome | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Diarrhea | 3 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thromboembolic event | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain in extremity | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Duodenal ulcer | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Syncope | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Neutrophil count decreased | 4 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nervous system disorders - Other, specify | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dyspnea | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Allergic reaction | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nausea | 4 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Muscle weakness lower limb | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Edema limbs | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Acute kidney injury | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Mucositis oral | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count increased | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Epistaxis | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Somnolence | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count decreased | 2 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphedema | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Facial pain | 1 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Skin ulceration | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lung infection | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Infections and infestations - Other, specify | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fall | 0 Participants |
| Sunitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anemia | 6 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Confusion | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Abdominal pain | 3 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Acute kidney injury | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Alanine aminotransferase increased | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Allergic reaction | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anemia | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anorexia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Aspartate aminotransferase increased | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Back pain | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dehydration | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Diarrhea | 2 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Duodenal ulcer | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dyspnea | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Edema limbs | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Epistaxis | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Facial pain | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fall | 2 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fatigue | 6 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Febrile neutropenia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Gastrointestinal disorders - Other, specify | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Generalized muscle weakness | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Genital edema | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hearing impaired | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hematoma | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypercalcemia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyperkalemia | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypermagnesemia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypertension | 14 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoalbuminemia | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypocalcemia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypomagnesemia | 2 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyponatremia | 3 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypophosphatemia | 6 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoxia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Infections and infestations - Other, specify | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lung infection | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphedema | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count decreased | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count increased | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Mucositis oral | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Muscle weakness lower limb | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nausea | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nervous system disorders - Other, specify | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Neutrophil count decreased | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain in extremity | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Palmar-plantar erythrodysesthesia syndrome | 9 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pancreatitis | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Paronychia | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Platelet count decreased | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pleural effusion | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pneumonitis | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Proteinuria | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Rash maculo-papular | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Renal calculi | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Reproductive system and breast disorders - Other | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus bradycardia | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus tachycardia | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Skin ulceration | 1 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Somnolence | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Syncope | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thromboembolic event | 6 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thrombotic thrombocytopenic purpura | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vascular disorders - Other, specify | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vomiting | 0 Participants |
| Cabozantinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | White blood cell decreased | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dyspnea | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoxia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Infections and infestations - Other, specify | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Facial pain | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lung infection | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Skin ulceration | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphedema | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Epistaxis | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count decreased | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Allergic reaction | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count increased | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Edema limbs | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | White blood cell decreased | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Mucositis oral | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Somnolence | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Muscle weakness lower limb | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fall | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nausea | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nervous system disorders - Other, specify | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Duodenal ulcer | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vomiting | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Neutrophil count decreased | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Syncope | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Diarrhea | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain in extremity | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Alanine aminotransferase increased | 2 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Palmar-plantar erythrodysesthesia syndrome | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dehydration | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pancreatitis | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thromboembolic event | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Paronychia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Confusion | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Platelet count decreased | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pleural effusion | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Back pain | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Abdominal pain | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pneumonitis | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thrombotic thrombocytopenic purpura | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Proteinuria | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Aspartate aminotransferase increased | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Rash maculo-papular | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Acute kidney injury | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Renal calculi | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anorexia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hearing impaired | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Genital edema | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hematoma | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Reproductive system and breast disorders - Other | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypercalcemia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Generalized muscle weakness | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyperkalemia | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypermagnesemia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Gastrointestinal disorders - Other, specify | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vascular disorders - Other, specify | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypertension | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus bradycardia | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoalbuminemia | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Febrile neutropenia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypocalcemia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anemia | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypomagnesemia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fatigue | 2 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyponatremia | 0 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus tachycardia | 1 Participants |
| Crizotinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypophosphatemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypercalcemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus tachycardia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Platelet count decreased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoxia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Facial pain | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Allergic reaction | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Back pain | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Infections and infestations - Other, specify | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Acute kidney injury | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Abdominal pain | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fall | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lung infection | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Epistaxis | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pleural effusion | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Reproductive system and breast disorders - Other | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphedema | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Sinus bradycardia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Skin ulceration | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyperkalemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count decreased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Edema limbs | 2 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pneumonitis | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Aspartate aminotransferase increased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Lymphocyte count increased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Gastrointestinal disorders - Other, specify | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Proteinuria | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Mucositis oral | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dyspnea | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vascular disorders - Other, specify | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thrombotic thrombocytopenic purpura | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Muscle weakness lower limb | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypermagnesemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Somnolence | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Rash maculo-papular | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nausea | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Duodenal ulcer | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Alanine aminotransferase increased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Anorexia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Nervous system disorders - Other, specify | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypocalcemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Fatigue | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Renal calculi | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Neutrophil count decreased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Diarrhea | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Genital edema | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypophosphatemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypertension | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Syncope | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hearing impaired | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pain in extremity | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Dehydration | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Febrile neutropenia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | White blood cell decreased | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Palmar-plantar erythrodysesthesia syndrome | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hyponatremia | 3 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Vomiting | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hematoma | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Pancreatitis | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Confusion | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Generalized muscle weakness | 1 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypomagnesemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Paronychia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Hypoalbuminemia | 0 Participants |
| Savolitinib | Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs | Thromboembolic event | 2 Participants |
Secondary
Overall Survival (OS)
Duration from date of randomization to date of death from any cause.
Time frame: Up to 3 years
Population: Analysis population included eligible participants.
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Sunitinib | Overall Survival (OS) | 16.4 months |
| Cabozantinib | Overall Survival (OS) | 20.0 months |
| Crizotinib | Overall Survival (OS) | 19.9 months |
| Savolitinib | Overall Survival (OS) | 11.7 months |
Comparison: The log-rank test will be used to compare OS.95% CI: [0.47, 1.51]Log Rank
Secondary
Response Rate (RR)
The response rate (RR) is defined as the combined rate of confirmed and unconfirmed partial response and confirmed and unconfirmed complete response. Complete response (CR) is defined as the complete disappearance of all target and non-target lesions, along with no new lesions. Partial response (PR) is defined as \>=30% decrease of the sum of appropriate diameters of all target measurable lesions, along with no new lesions.
Time frame: Up to 3 years
Population: Analysis population included eligible participants.
| Arm | Measure | Value (NUMBER) |
|---|---|---|
| Sunitinib | Response Rate (RR) | 4.35 percentage of participants |
| Cabozantinib | Response Rate (RR) | 22.73 percentage of participants |
| Crizotinib | Response Rate (RR) | 0 percentage of participants |
| Savolitinib | Response Rate (RR) | 3.45 percentage of participants |
Comparison: The Chi-Square test will be used to compare RR between sunitinib and cabozantinib.p-value: 0.1Chi-squared
Other Pre-specified
MET Mutation Rate
The hazard ratio between the MET inhibitor versus (vs.) sunitinib in those with versus without the mutation (i.e., the interaction) will be compared. Response Evaluation Criteria in Solid Tumors (RECIST) response rate (confirmed and unconfirmed partial response and complete response) based on MET mutation/expression level will be compared using the chi-square test.
Time frame: Up to 3 years