Infant, Very Low Birth Weight
Conditions
Brief summary
In Canada, the leading cause of long-term disability in children is being born at very low birth weight (VLBW). To help improve outcomes, nutrition is a modifiable aspect of infant care. Mother's milk is the optimal way to feed VLBW infants; however, many need a supplement of donor milk or preterm formula as not enough mother's milk is available. As the ideal supplement for prolonged feeding and its long-term effects is currently unknown, this study is a prospective follow up of VLBW infants who in hospital were fed: donor milk or preterm formula and/or mother's milk. Areas of development to be assessed include: cognition, language, motor skills, brain structure/function, and body composition. A DNA biorepository will also be created.
Interventions
OTHERPasteurized donor human breastmilk
OTHERPreterm formula
Sponsors
The Hospital for Sick Children
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 6 Years
Inclusion criteria
* Children who were enrolled in the DoMINO (Donor Milk for Improved Neurodevelopmental Outcomes) trial (ISRCTN35317141).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Full-Scale IQ on the Wechsler Preschool and Primary Scale of Intelligence-IV (WPPSI-IV) | 5.5 years of age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Performance IQ on the WPPSI-IV | 5.5 years of age | — |
| General Language Composite on the WPPSI-IV | 5.5 years of age | — |
| Verbal IQ on the WPPSI-IV | 5.5 years of age | — |
| Growth | 5.5 years of age | Growth as assessed using weight, height and waist circumference measurements. |
| Body Composition | 5.5 years of age | Body composition as assessed using the COSMED BOD POD and skinfold thickness. |
| Processing Speed Quotient on the WPPSI-IV | 5.5 years of age | — |
Other
| Measure | Time frame | Description |
|---|---|---|
| Memory domain on the NEPSY-II | 5.5 years of age | — |
| Influence of the diet on epigenetic changes | 5.5 years of age | Assessed using a buccal cell biorepository. |
| Visual-Motor Integration using the Beery | 5.5 years of age | — |
| School Readiness using the Early Development Instrument (EDI) | 5.5 years of age | — |
| Development of Brain Structure | 5.5 years of age | Development of brain structure as assessed using Magnetic Resonance Imaging (MRI). |
| Development of Brain Function | 5.5 years of age | Development of brain function as assessed using Magnetoencephalography (MEG). |
| Interaction of genetic differences and feeding type on outcomes | 5.5 years of age | Assessed using a buccal cell biorepository. |
| Affect Recognition domain on the NEPSY-II | 5.5 years of age | — |
| Language domain on the NEPSY-II | 5.5 years of age | — |
Countries
Canada
Outcome results
None listed