Spontaneous Bacterial Peritonitis
Conditions
Brief summary
One of the most common and serious complications in decompensated cirrhotic patients (DCPs) is bacterial infection.The most common infections in DCPs are cases of spontaneous bacterial peritonitis (SBP), which account for 40% 70% of cases, followed by urinary tract infections, pneumonia and cellulitis. Serum amyloid A (SAA) and C-reactive protein (CRP) are acute-phase proteins predominantly produced and secreted by hepatocytes. Other cells including lymphocytes, monocytes, and macrophages can also produce these proteins. The induction of SAA and CRP synthesis is triggered by a number of cytokines, chiefly IL-6, which is released from a variety of cell types, but mainly from macrophages and monocytes at inflammatory sites
Detailed description
Increased serum CRP and SAA levels have been found in a number of disorders, including bacterial infections, malignancies tissue injuries and tissue rejection. Therefore, new studies of early diagnosis, prevention and treatment are needed to improve clinical outcomes.
Interventions
serum amyloid A level (SAA)
Sponsors
Tanta University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* • Decompansated cirrhosis with ascites, defined by a combination of any of the following: * Laboratory findings * Endoscopic results * Ultrasound * Histology
Exclusion criteria
* Creatinine\>1.5 mg/dl * Other infection e.grespiratory,UTI ,gastrointestinal and skin infection. * Hepatocellular carcinoma * Other extrahepatic malignancy e.g ; chest * Any significant psychiatric illness or other medical comorbidity. * Any degenerative diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients with elevated serum amyloid A | 6months |
Countries
Egypt
Contacts
Primary ContactSherief Abd-Elsalam, Consultant
Outcome results
None listed