Myocardial Deformation Imaging After Acute Alcohol Excess

Detection of Early Changes in Left Ventricular Function by Myocardial Deformation Imaging After Acute Excessive Alcohol Ingestion

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02759445

Acronym

Enrollment

200

Registered

2016-05-03

Start date

2016-04-30

Completion date

2016-10-31

Last updated

2016-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Dysfunction

Keywords

alcohol induced cardiomyopathy, myocardial deformation imaging

Brief summary

Background: Chronic excessive alcohol consumption leads to progressive and chronic cardiac dysfunction. In general, patients consuming alcohol more than five years are at risk for the development of dilated cardiomyopathy. As only few data about immediate changes in left ventricular function after acute excessive alcohol ingestion are available, this study sought to close this gap. Methods: 200 subjects (not used to alcohol, no cardiac disease) will be examined up to 12 hours after alcohol excess and after 4 weeks of complete alcohol abstinence. Echocardiography will performed at baseline and at follow-up regarding conventional parameter \[as left ventricular ejection fraction (LVEF), transmitral early (E) and late (A) Doppler flow velocities, E/A ratio, deceleration time of E (DT) and isovolumic relaxation time (IVRT)\] and myocardial deformation data \[as layer specific global circumferential (endo GCS, mid GCS, epi GCS) and longitudinal (endo GLS, mid GLS, epi GLS) strain\].

Interventions

OTHERroutine treatment

No intervention, only observation and describing

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects who are not used to alcohol * subjets who had an excessive alcohol Ingestion up to 12 hours before echocardiography

Exclusion criteria

* any heart disease * subjects under 18 years

Design outcomes

Primary

Measure	Time frame	Description
Myocardial Dysfunction by echocardiographic parameters	At 4 weeks follow-up	Conventional echocardiographic parameters as left ventricular ejection fraction (measured in %) and volumes (measured in ml) and myocardial Deformation parameters as global and layer specific radial, longitudinal and circumferential strain (all measured in %) will be determined

Secondary

Measure	Time frame	Description
Change from baseline in echocardiographic parameters	from baseline to follow up at 4 weeks	These echocardiographic parameters will be determined at baseline and at 4 weeks follow up and the changes (assessed by percentage differences) will be given

Countries

Germany

Contacts

Primary ContactMichael Becker, Prof.

mibecker@ukaachen.de0049-241-8037137

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026