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Suicide Prevention Intervention for At-Risk Individuals in Transition

Suicide Risk Reduction in the Year Following Jail Release: the SPIRIT Trial (Suicide Prevention Intervention for At-Risk Individuals in Transition)

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02759172
Acronym
SPIRIT
Enrollment
800
Registered
2016-05-03
Start date
2016-04-01
Completion date
2019-12-31
Last updated
2025-12-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Suicide

Keywords

Suicide prevention, Jail

Brief summary

The four year SPIRIT Trial, or Suicide Prevention Intervention for at-Risk Individuals in Transition, will recruit 800 pretrial jail detainees at risk for suicide. Each participant will be randomly assigned to today's standard care or to Safety Planning Intervention (SPI) method and then followed for one year after release. Outcomes include suicide events, suicide attempts and ideation, psychiatric symptoms, functioning, treatment utilization, problem-solving, belongingness, and cost-effectiveness.

Detailed description

There were nearly 12 million admissions to US jails in 2012. Jailed individuals face a disproportionate risk for suicide. The time of arrest and jail detention represents an acute stressor that further exacerbates this risk. The epidemic of suicide during jail detention has been recognized. However, less attention has been paid to the high suicide risk and mortality in the months following jail release, as individuals re-enter their communities, are faced with financial, legal, and social stressors, and have increased access to lethal means (e.g., drugs, cars, firearms). Given that roughly 10% of all suicides in the U.S. with known circumstances occur following a recent criminal legal stressor (often arrest and jail detention), reducing suicide risk in the year after jail detention could have a noticeable impact on national suicide rates. Unlike prison, where individuals have already been sentenced and typically stay from months to years, most pretrial jail detainees are released within days. Therefore, brief interventions are required. Stanley and Brown's Safety Planning Intervention (SPI) is a brief, adjunctive suicide risk reduction intervention developed for suicidal patients presenting to urgent care settings. SPI incorporates evidence-based suicide risk reduction strategies in a low intensity, low cost intervention that can be delivered by a broad range of clinicians, making it scalable in the mental health resource-poor justice system. SPI reduces subsequent suicidal ideation and attempts among at-risk individuals in emergency rooms. However, there is no previous test of this intervention (or any other) for reducing suicidality following jail release. This RCT evaluates the effectiveness and cost-effectiveness of SPI for reducing suicide events (attempts, suicide behaviors, and suicide-related hospitalizations and emergency department visits) and attempts among 800 suicidal pretrial jail detainees from two jails in the year following jail release. It assesses critical mechanisms of suicide reduction in our target population: treatment utilization, suicide-related problem-solving, and belongingness. SPI will consist of safety planning during jail detention and follow-up phone sessions after jail release. Research with previously incarcerated individuals and with suicidal individuals in the community has shown that telephone follow-up intervention is feasible and powerful in building trust and reducing risk among these disenfranchised, isolated populations. This study will be the first randomized evaluation of a suicide prevention intervention in the vulnerable year after jail release. Beyond the human suffering and costs at an individual level, suicidal behavior incurs high economic costs in terms of health care costs and lost productivity. Jails are a catchment area for at-risk individuals at a time of high life stress and high suicide risk, providing an important opportunity for suicide prevention intervention, one that is currently being missed. This study will provide the data on costs and cost-adjusted outcomes that systems need to make informed decisions about adoption, speeding implementation. Thus, this study will contribute to knowledge about both mechanisms of action and system-level intervention effects.

Interventions

Brown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services.

Sponsors

Brown University
CollaboratorOTHER
Michigan State University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Unsentenced male and female pretrial jail detainees * 18+ years of age * at risk for suicide, operationalized as a response of yes on item 4 or greater on the initial 5 C-SSRS screening questions, indicating the presence of at least some active suicide ideation with some intent to act in the past month (i.e., individuals at higher risk, such as those who report intent with specific plan and/or suicide attempt/s in the last month, will also be included); * speak and understand English well enough to understand questionnaires when they are read aloud.

Exclusion criteria

* expects to be sentenced and serve their sentence before being released to the community * cannot provide the name and contact information of at least two locator persons * does not have access to any telephone.

Design outcomes

Primary

MeasureTime frameDescription
Suicide EventsOne year after jail releaseNumber of suicide events (a composite of attempts, behaviors, suicide-related hospitalizations, and suicide deaths) in the year following jail release. Events are identified through self-report, hospital records, and death records.

Secondary

MeasureTime frameDescription
Weeks of Active Suicide IdeationOne year after release from jailOperationalized using the Longitudinal Interval Follow-Up Evaluation (LIFE)
Severity of Suicide IdeationAssessed 1, 4, 8, and 12 months after release from jail, 12 months reported.Columbia Suicide Severity Rating Scale (C-SSRS) Suicide Intensity Subscale score. Subscale scores range from 2 to 25, higher scores indicating more intense suicidal ideation.
Time to First Suicide EventOne year after release from jail
Psychiatric SymptomsAssessed 1, 4, 8, and 12 months after release from jail, 12 months reported.NIH's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Cross-Cutting Measure total score. Scores range from 0 to 92, higher scores reflecting greater severity of psychiatric symptoms.
Suicide AttemptsOne year after release from jailNumber of suicide attempts using the Columbia (C-SSRS) criteria.
Treatment UtilizationAssessed 1, 4, 8, and 12 months after release from jail, 12 months reported.Number of outpatient mental health and substance use visits attended
Suicide-related Problem-solvingAssessed 1, 4, 8, and 12 months after release from jail, 12 months reported.Suicide-Related Coping Scale total score. Scores range from 0-68, higher scores indicating better suicide related coping.
BelongingnessAssessed 1, 4, 8, and 12 months after release from jail, 12 months reported.Interpersonal Needs Questionnaire-12 (INQ-12) belongingness subscale score. Scores range from 0-54, higher scores indicating higher levels of thwarted belongingness.
FunctioningAssessed 1, 4, 8, and 12 months after release from jail, 12 months reported.Veterans RAND 12-Item Health Survey (VR-12) total score. Scores range from 0 to 100, higher scores indicating greater functioning.

Countries

United States

Participant flow

Participants by arm

ArmCount
Safety Planning Intervention
Brown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services. Safety Planning Intervention: Brown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services.
342
Standard Care
Standard Care for pretrial jail detainees is assessment of risk and stabilization to the extent possible during their jail detention. No post-release community follow-up is typically provided. This study will augment standard care with regular assessment and emergency referral post-release, as well as provision of a list of community resources.
313
Total655

Baseline characteristics

CharacteristicSafety Planning InterventionStandard CareTotal
Age, Continuous32.8 years
STANDARD_DEVIATION 10.2
33.2 years
STANDARD_DEVIATION 10.5
33 years
STANDARD_DEVIATION 10.4
Race/Ethnicity, Customized
All other groups and not-specified
45 Participants32 Participants77 Participants
Race/Ethnicity, Customized
American Indian or Alaskan Native
39 Participants32 Participants71 Participants
Race/Ethnicity, Customized
Black or African American
83 Participants76 Participants159 Participants
Race/Ethnicity, Customized
Hispanic Ethnicity
49 Participants38 Participants87 Participants
Race/Ethnicity, Customized
Non-Hispanic Ethnicity
293 Participants275 Participants568 Participants
Race/Ethnicity, Customized
White
175 Participants173 Participants348 Participants
Sex: Female, Male
Female
98 Participants84 Participants182 Participants
Sex: Female, Male
Male
244 Participants229 Participants473 Participants

Adverse events

Event typeEG000
affected / at risk
EG001
affected / at risk
deaths
Total, all-cause mortality
12 / 3424 / 313
other
Total, other adverse events
70 / 34269 / 313
serious
Total, serious adverse events
177 / 342159 / 313

Outcome results

Primary

Suicide Events

Number of suicide events (a composite of attempts, behaviors, suicide-related hospitalizations, and suicide deaths) in the year following jail release. Events are identified through self-report, hospital records, and death records.

Time frame: One year after jail release

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionSuicide Events1.8 number of eventsStandard Deviation 3.4
Standard CareSuicide Events3.0 number of eventsStandard Deviation 7.2
Secondary

Belongingness

Interpersonal Needs Questionnaire-12 (INQ-12) belongingness subscale score. Scores range from 0-54, higher scores indicating higher levels of thwarted belongingness.

Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionBelongingness19.90 score on a subscaleStandard Error 0.77
Standard CareBelongingness20.08 score on a subscaleStandard Error 0.81
Secondary

Functioning

Veterans RAND 12-Item Health Survey (VR-12) total score. Scores range from 0 to 100, higher scores indicating greater functioning.

Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionFunctioning72 score on a scaleStandard Deviation 18.9
Standard CareFunctioning72.3 score on a scaleStandard Deviation 19.2
Secondary

Psychiatric Symptoms

NIH's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Cross-Cutting Measure total score. Scores range from 0 to 92, higher scores reflecting greater severity of psychiatric symptoms.

Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionPsychiatric Symptoms44.1 score on a scaleStandard Deviation 18.4
Standard CarePsychiatric Symptoms45 score on a scaleStandard Deviation 19.3
Secondary

Severity of Suicide Ideation

Columbia Suicide Severity Rating Scale (C-SSRS) Suicide Intensity Subscale score. Subscale scores range from 2 to 25, higher scores indicating more intense suicidal ideation.

Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionSeverity of Suicide Ideation15.2 score on a subscaleStandard Deviation 7.7
Standard CareSeverity of Suicide Ideation16.2 score on a subscaleStandard Deviation 7.1
Secondary

Suicide Attempts

Number of suicide attempts using the Columbia (C-SSRS) criteria.

Time frame: One year after release from jail

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionSuicide Attempts1 Number of attemptsStandard Deviation 2.7
Standard CareSuicide Attempts2.1 Number of attemptsStandard Deviation 6.4
Secondary

Suicide-related Problem-solving

Suicide-Related Coping Scale total score. Scores range from 0-68, higher scores indicating better suicide related coping.

Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionSuicide-related Problem-solving65.82 score on a scaleStandard Error 0.66
Standard CareSuicide-related Problem-solving65.39 score on a scaleStandard Error 0.69
Secondary

Time to First Suicide Event

Time frame: One year after release from jail

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionTime to First Suicide Event7.4 weeksStandard Deviation 6.3
Standard CareTime to First Suicide Event4.4 weeksStandard Deviation 3.8
Secondary

Treatment Utilization

Number of outpatient mental health and substance use visits attended

Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionTreatment Utilization9.02 number of visitsStandard Error 0.88
Standard CareTreatment Utilization8.41 number of visitsStandard Error 0.86
Secondary

Weeks of Active Suicide Ideation

Operationalized using the Longitudinal Interval Follow-Up Evaluation (LIFE)

Time frame: One year after release from jail

ArmMeasureValue (MEAN)Dispersion
Safety Planning InterventionWeeks of Active Suicide Ideation9 weeksStandard Deviation 11.5
Standard CareWeeks of Active Suicide Ideation10.9 weeksStandard Deviation 13.1

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026