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The Study of Mechanism of Alzheimer's Disease Using Acupuncture Based on fMRI

The Study of Brain Functional Network Modulatory Mechanism of Alzheimer's Disease Using Acupuncture at the Four-gate Acupoints

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02759159
Enrollment
120
Registered
2016-05-03
Start date
2016-06-30
Completion date
2018-12-31
Last updated
2016-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease

Brief summary

Alzheimer's disease (AD) is one of the major brain diseases which received more attention in recent years. The disconnection syndrome is the main pathophysiological mechanism leading to cognitive decline in AD patients. Both animal experiment and clinical observation have demonstrated that acupuncture can generate treatment effect on AD patients by moderating the neural pathway directly. However, the underlying mechanism remains unclear. By using resting state functional magnetic resonance imaging (fMRI) method, as well as acupuncture and neurology sciences, investigators will explore the multi-modality data analysis; compare brain connectivity and network parameters changes between pre- and post- acupuncture treatment; analyze the correlation between fMRI changes and neuropsychology test. The present study aims to elucidate the neural mechanism of acupuncture therapy on early AD, provide theoretical evidence from the perspective of functional connectivity.

Interventions

PROCEDUREtrue acupuncture

acupuncture at the four-gateacupoints, three times per week and last for 6 months

PROCEDUREsham acupuncture

acupuncture at the places 1cm from the true four-gate acupoints,three times per week and last for 6 months

Sponsors

Xuanwu Hospital, Beijing
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

Clinical diagnosis of Alzheimer's Disease Clinical diagnosis of MCI due to Alzheimer's Disease Drug therapy regularly

Exclusion criteria

Frontotemporal dementia Lewy body dementia Vascular dementia Severe depression Brain vascular disease Metabolic disease

Design outcomes

Primary

MeasureTime frameDescription
brain functional connectivitywith in first week after the whole acupuncture treatmentGE750 3.0T gradient-echo single-shot echo plannar imaging TR=2000ms TE=30ms slice=36 slice thickness=3mm gap=1mm volumes=180

Countries

China

Contacts

Primary ContactKuncheng Li, Doctor
cjr.likuncheng@vip.163.com+861083198376
Backup ContactHui Li
810009062@qq.com+861083198376

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026