Echocardiography, Heart; Decompensation, Right Ventricle, Hypercapnia
Conditions
Brief summary
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography.
Detailed description
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.
Interventions
PROCEDUREHypercarbia
PaCO2 is elevated from 5 to 7.5 kPa by controlled ventilation.
Sponsors
Tampere University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* scheduled mitral valve prolapse repair surgery * able to give informed consent
Exclusion criteria
* preoperative right ventricular dysfunction or pulmonary hypertension * significant tricuspid regurgitation * congenital heart defect * ventricular dyssynchrony or wide QRS-complex on ECG (\> 130 ms) * prior myocardial infarction (within tree months) or pericardial constriction * preoperative left ventricular (LV) dysfunction, i.e. LV ejection fraction under 40 % * if the scheduled repair by plastic procedure has been converted to mitral valve replacement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tricuspid annular plane systolic excursion (TAPSE) | Change from baseline TAPSE at hypercarbia (in approximately 30 min) | TAPSE will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa) |
| Mean pulmonary artery pressure (MPAP) | Change from baseline MPAP at hypercarbia (in approximately 30 min) | MPAP will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa) |
Countries
Finland
Outcome results
None listed