Oral Contraceptives as Infertility Treatments for Premature Ovarian Failure

Drospirenone and Ethinyl Estradiol Combinations (Yasmin) as Infertility Treatments for Premature Ovarian Failure: a Perspective Follow-up Study.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02757469

Enrollment

Registered

2016-05-02

Start date

2016-05-31

Completion date

2021-05-31

Last updated

2016-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopause, Premature, Primary Ovarian Insufficiency

Brief summary

Premature ovarian insufficiency (POI) is a life-changing condition that affects women in their reproductive age. There is a lack of reports which focus on how to improve the reproductive outcome of these women who wish to conceive spontaneously or use assisted conception with their own oocytes. However, one could surmise that it is important to lower gonadotropin levels into the physiological range before embarking on any treatment, even if natural conception is the only choice for the woman/couple.

Interventions

DRUGDrospirenone and ethinyl estradiol combination (Yasmin)

Female oral combined contraceptive containing 30 mcg (0.030 mg) Ethinyl Estradiol and 3 mg drospirenone (Androstenes)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* premature ovarian failure * normal anatomy * normal secondary sexual characteristics * essential or idiopathic

Exclusion criteria

* chromosomal disorder * iatrogenic injury * autoimmune diseases * infection * genetic diseases

Design outcomes

Primary

Measure	Time frame	Description
live birth	3 years	The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).

Secondary

Measure	Time frame	Description
clinical pregnancy rate	3 years	The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
multiple pregnancy	3 years	The condition of carrying two or more FETUSES.
miscarriage	3 years	Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.

Countries

China

Contacts

Primary ContactYunhai Chuai, Dr

wangyh85@foxmail.com+86-18810892004

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026