Ischemia
Conditions
Brief summary
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx. The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
Detailed description
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order. 1. Preoperation (immediate before anesthesia induction) 2. Immediate before tourniquet off 3. 5 min after tourniquet off 4. PACU 5. postoperative 6 hours 6. postoperative 24 hours Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay
Interventions
DRUGpropofol group
Patient will be anesthetized by using propofol infusion during operation.
DRUGDesflurane group
Patient will be anesthetized by using desflurane inhalation during operation.
Sponsors
Konkuk University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients who was planned to undergo knee surgery.
Exclusion criteria
* age \< 20 years old * history of previous cancer * history of previous peripheral vascular disease * Emergency surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Syndecan-1 | Preoperative time, Immediate before tourniquet off,5 min after tourniquet off,PACU, postoperation after 6hours, postoperation after 24hours | change of level of syndecan-1 (scores range from 0 to 100) |
Countries
South Korea
Outcome results
None listed