Postoperative; Dysfunction Following Cardiac Surgery
Conditions
Keywords
sufentanil, propofol, personality/stress test, fast-track
Brief summary
Patients scheduled for elective cardiac surgery are preoperative evaluated using different personality type, stress and anxiety tests. Patient are randomized to receive the investigators' standard moderate dose sufentanil (bolus 1microgram/kg and propofol 0.03 mg/kg/min) or low dose sufentanil (bolus 0.5 microgram/kg and propofol 0.06 mg/kg/min).
Detailed description
Patients randomized and the type of induction informed to the anaesthetist 30 minutes before surgery. Patients are monitored before induction of anesthesia. Propofol is started on the randomized infusion rate. Sufentanil bolus are given according to randomization. BIS level is followed. Time to reach BIS \< 50 is monitored. BIS after 30, 60 and 90 minutes are registered. Lowest BIS during surgery are registered. Total amounts of sufentanil and propofol recorded.
Interventions
DRUGSufentanil I
bolus dose of sufentanil 1 microgram/kg
DRUGSufentanil II
bolus dose of sufentanil 0.5 microgram/kg
DRUGPropofol I
Continued dose of propofol 0.03 mg/kg/min
DRUGPropofol II
Continued dose of propofol 0.06 mg/kg/min
Sponsors
Aarhus University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Age
16 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* All elective cardiac surgery patients
Exclusion criteria
* Patients requiring special attention or monitoring during induction * Patients with expected longer postoperative ventilation time * Patients allergic to sufentanil and or propofol * Participation in other projects * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association between preoperative personality/stress/anxiety and time (minutes) to reach anaesthetic depth goal by bi-spectral index (BIS) | Up to 30 minutes | Minutes to reach BIS 50 |
| Potential of sufentanil regime on fast-track measured by ventilation time and association with eligible discharge from intensive care unit. | Up to 24 hours | Postoperative ventilation time (hours/minutes) and the association to eligible discharge from ICU. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sufentanil regime and association to haemodynamic parameters (blood pressures, heart rate, cardiac output, oxygenation) | up to 24 hours | Perioperative changes in haemodynamic parameters (analysis of varians) of haemodynamic parameters according to sufentanil regime |
| Association between preoperative personality/stress/anxiety tests and postoperative care using postoperative quality score | up to 24 hours | Association of preoperative tests and the postoperative ICU quality scoring |
| Association between preoperative personality/stress/anxiety and total amounts of sufentanil and propofol | Up to 12 hours | Amounts of drugs as pr kg pr time unit of involved drugs |
Outcome results
None listed