Acute Coronary Syndrome
Conditions
Brief summary
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).
Detailed description
The present study is a single-center, prospective diagnostic study among patients presenting to the ED or ICU within 24 h of onset of chest pain suggestive of suspected ACS. We propose to construct the biobank of ACS and evaluate the potential diagnostic value of circulating microRNAs compared with cTnI for suspected ACS patients. All the patients are to be followed up for 6 months. Final diagnosis was made by an expert panel cardiologist, based on all available clinical information including cTnI measurements, ECG, coronary angiography, cardiac exercise tests and information from hospital discharge letters. The concentrations of microRNAs will be evaluated by quantitative reverse transcription PCR, using highly specific primers and hybridization probes.
Interventions
None listed
Sponsors
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
Suspected ACS patients (STEMI, NSTEMI, and UA): Age\>18 years; Informed consent.
Exclusion criteria
Patients who will undergo immediate PCI; Pregnant and lactating women; Patients with mental disorders; Patients are using other experimental drugs; Refusal to provide informed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the diagnostic value of microRNAs in qPCR，in ACS | Day 7 |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the prognostic value of microRNAs in ACS | 6 months |
Countries
China
Contacts
Primary Contactbin he
Backup Contacthuimin cao
Outcome results
None listed