Motility Disorder of Intestine
Conditions
Brief summary
This project involves the development, validation and application of a novel test using MRI to assess gastrointestinal motility a vital process that mixes the contents of our digestive tract. This process frequently becomes deranged in conditions like chronic constipation, Parkinson's and Crohn's disease.
Detailed description
Gastrointestinal motility refers to the contractile actions in the gut that serve to mix our food and propel it through out digestive tract. Although known to be involved in a range of conditions like chronic constipation, Parkinson's and Crohn's disease, investigator have never had effective tests with which to study the process. Advances in medical imaging technologies now make it possible to both see and quantify this process non-invasively using MRI. In this study the investigator first of all validate that our MRI based analysis is robust and valid, producing predictable results against range of known stimuli. The investigator then apply the technique to a cohort of participants with Chronic Intestinal Pseudo-Obstruction. These participants are known to have hypo-motile small bowels and demonstration with our MRI technique would serve as further validation. The investigator also investigate two cohorts of people with and without gastrointestinal diseases to better understand how the technique may work in the clinical setting. By the end of this project The investigator will have generated robust initial evidence to validate our MRI technique and clinical data to inform use further research.
Interventions
None listed
Sponsors
University College, London
Study design
Observational model
CASE_ONLY
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
ELIGIBILITY CRITERIA - CONTROL SUBJECTS DRUG STUDY: * Adult (\>16 years) * Body Mass Index within the range of (18---25) ELIGIBILITY CRITERIA - DYSMOTILITY SUBJECTS DRUG STUDY: * Adult patients (\>16 years) 2 * Dysmotility diagnosis including CIPO * Body Mass Index within the range of (18---35) ELIGIBILITY CRITERIA - REFERENCE RANGE STUDY (NORMAL PARTICIPANTS): • Adult (\>16 years) ELIGIBILITY CRITERIA - REFERENCE RANGE STUDY (DYSMOTILITY/IBS): * Adult patients (\>16 years) * Dysmotility, CIPO or IBS diagnosis ELIGIBILITY CRITERIA - DYSMOTILITY REVERSIBILITY STUDY: * Adult (\>16 years) * Known small bowel Crohn's disease starting anti TNF alpha medication or undergoing endoscopic small bowel stricture dilatation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To establish the reproducibility of software quantified small bowel motility in normal individuals using processed MRI derived dynamic small bowel sequences. | 7 years |
| To assess the ability of the software to detect changes in small bowel motility after provocation with a known pro or anti-kinetic agent in normal individuals | 7 years |
| To evaluate the variation in software quantified small bowel motility according to the positioning of the image slice in the abdomen during data acquisition. | 7 years |
| To compare dysmotility patients motility to that of normal controls with and in the absence of pro---kinetic agent. | 7 years |
| To establish basal bowel motility reference ranges in a larger cohort of control, dysmotility and irritable bowel syndrome subjects. | 7 years |
| To assess the reversibility of dysmotility after treatment of the primary underlying condition, if known | 7 years |
Countries
United Kingdom
Contacts
Primary ContactAlex Menys
Outcome results
None listed