Cerebral Blood Flow Regulation and Concussions

Association Between Brain Blood Flow Regulation, Cognition, and Balance in Sports-Related Concussion

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02754206

Enrollment

Registered

2016-04-28

Start date

2016-01-31

Completion date

2021-09-01

Last updated

2021-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Concussion, Post-Concussion Syndrome

Brief summary

The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.

Detailed description

Comparisons will be made between control data and data following a concussion collected from athletes participating in contact-collision sports. For those suffering a concussion, comparisons will be made between day 3 (acute phase), day 21 (recovery phase), and 3 months post-concussion.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Student athletes actively participating in collegiate sports. Subjects should be wiling to provide informed consent for participation in the study.

Exclusion criteria

* Participants who are unable to play as a result of injury. Presence of irregular heart beat.

Design outcomes

Primary

Measure	Time frame	Description
Cerebral blood flow regulation	Change in Control, 3 days post concussion, 21 days post concussion, and 3 months post concussion	Subject's cerebral blood flow regulation (cm/sec) at rest, during a cognitive test, and during a breathing test will be measured.

Secondary

Measure	Time frame	Description
Blood Biomarkers	Control, 3 days post concussion, 21 days post concussion, 3 months post concussion	Subjects will have their blood drawn so investigators can look at biomarkers in their blood. The biomarkers will be Tau, a-Spectrin N-Terminal Fragment, Neuron-specific enolase, Ubiquitin C-Terminal hydrolase L1, S100B, and Glial fibrillary acidic protein.
Memory Function Test	Control, 3 days post concussion, 21 days post concussion, 3 months post concussion	Subjects will be given paper tests to test their memory function.
Balance Test	Control, 3 days post concussion, 21 days post concussion, 3 months post concussion	Subjects balance will be measured using a force plate.
Orthostatic Tolerance Test	Control, 3 days post concussion, 21 days post concussion, 3 months post concussion	Subjects physiological measurements will be measured as the move from a seated position to a standing position.
Cerebral Vasoreactivity	Control, 3 days post concussion, 21 days post concussion, 3 months post concussion	Subjects will breathe normal air, a 8% carbon dioxide gas mixture, and hyperventilate.

Countries

United States

Outcome results